Mesoscopic relaxation time of dynamic image correlation spectroscopy

DOI: 10.4236/jbise.2010.36085   PDF   HTML     4,042 Downloads   7,163 Views   Citations


Dynamical images contain useful information of how the objects behave in time and space. When the system is in biological fluids, the motion of the object is much over-damped; the relaxation time is the characteristics in a diffusive time scale. We have found dynamical states of melting and forming of small nematic domains (10—30 μm) that are exhibited in the suspensions of fd-viruses under applied AC electric field amplitude at low frequency. Dynamic image correlation function is used for extracting the mes- oscopic relaxation times of the dynamical states, which can be employed as an application to other dynamic imaging process of biologically relevant soft condensed matter and biomedical systems.

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Kang, K. (2010) Mesoscopic relaxation time of dynamic image correlation spectroscopy. Journal of Biomedical Science and Engineering, 3, 625-632. doi: 10.4236/jbise.2010.36085.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Eason, G., Brix, G., Kiessling, F., Lucht, R., Darai, S., Wasser, K., Delorme, S. and Griebel, J. (2004) Micro- circulation and microvasculature in breast tumors: Ph- armacokinetic analysis of dynamic MR image series. Magnetic Resonance in Medicine, 52, 420-429.
[2] Donahue, K.M., Weisskoff, R.M. and Burstein, D. (1997) Water diffusion and exchange as they influence contrast enhancement. Journal of Magnetic Resonance Imaging, 7, 102-110.
[3] Peter, K., Nilsson, R., Aslund, A., Berg, I., Nystrom, S., Konradsson, P., Herland, A., Inganas, O., Stabo-Eeg, F., Lindgren, M., Westermark, G.T., Lannfelt, L., Nilsson, L.N.G. and Hammarstrom, P. (2007) Imaging distinct conformational states of amyloid-β fibrils in Alzheimer’s Diseases using novel luminescent probes. ACS Chemical Biology, 2, 553-560.
[4] Wiseman, P. and Peterson, N.O. (1999) Image cor- relation spectroscopy II, optimization for ultrasensitive detection of preexisting platelet-derived growth factor- βreceptor oligomers on intact cells. Biophysical Journal, 76, 963-977.
[5] Costantino, S., Comeau, J.W.D., Kolin, D.L. and Wisemann, P. (2005) Accuracy and dynamic range of spatial image correlation and cross-correlation spectroscopy. Bioph- ysical Journal, 89, 1251-1260.
[6] Kang, K. and Dhont, J.K.G. (2010) Electric-field induced transitions in suspensions of charged colloidal rods. Soft Matter, 6, 273-286.
[7] Kang, K. (2009) Image and signal correlation of electric- field induced charged fibrous viruses (fd). Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, 1294-1297.
[8] Csibra, G., Davis, G., Spratling, M.W. and Johnson, M.H. (2000) Gamma oscillations and object processing in the infant brain. Science, 290(5496), 1582-1585.
[9] Baudry, C. and Bertrand, T.O. (1999) Oscillatory gamma activity in humans and its roles in object representation. Trends in Cognitive Sciences, 3(4), 151-162.
[10] Sambrook, J., Fritch, E.F. and Maniatis, T. (1989) Molecular cloning: A laboratory manual. Cold Spring Harbor, New York.
[11] Lipka, J.J., Lippard, S.J. and Wall, J.S. (1979) Visua- lization of polymercurimethane-labeled fd-bacteriophage in the scanning transmission electron microscope. Science, 206(4425), 1419-1421.
[12] Cross, T.A. and Opella, S.J. (1979) NMR of fd coat protein. Journal of Supramolecular Structure, 11(2), 139-145.
[13] Gall, G.M., Cross, T.A., Diverdi, J.A. and Opella, S.J. (1982) Protein dynamics by solid state NMR: Aromatic rings of the coat protein in fd bacteriophase. Proceedings of the National Academy of Sciences, 79(1), 101-105.
[14] Schwind, P., Kramer, H., Kremser, A., Ramsberger, U. and Rasched, I. (1992) Subtilisin removes the surface layer of the phage fd coat. European Journal of Biochemistry, 210(2), 431-436.
[15] Newman, J., Swinney, H.L. and Day, L.A. (1977) Hydro- dynamic properties and structure of fd-virus. Journal of Molecular Biology, 116(3), pp. 593-606.
[16] Kang, K., Wilk, A., Patkowski, A. and Dhont, J.K.G. (2007) Diffusion of spheres in isotropic and nematic networks of rods: Electrostatic interactions and hydro- dynamic screening. Journal of Chemical Physics, 126(21), 214501-(1-17).
[17] Zimmermann, K., Hagedorn, J. Heuck, C.C., Hinr- ichsen, M. and Ludwig, J. (1986) The ionic properties of the filamentous bacteriophage Pf1 and fd. The Journal of Biological Chemistry, 261, 1653-1655.
[18] Kang, K. and Dhont, J.K.G. (2009) Criticality in a non- equilibrium, driven system: Charged colloidal rods (fd- viruses) in electric fields. The European Physical Journal E, 30(3), 333-340.

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