A Patient with Intravenous Immunoglobulin-Responsive Lower Motor Neuron Syndrome

Takaomi Kessoku, Takashi Koide, Katsunori Akiyama, Sachiko Irie, Tadayuki Ishihara, Fumihito Yoshii

2Department of Neurology, Hiratsuka City Hospital, Hiratsuka, Japan.
Department of Internal Medicine, Hiratsuka City Hospital, Hiratsuka, Japan.
Department of Neurology, Hiratsuka City Hospital, Hiratsuka, Japan.
Department of Neurology, Kitasato University School of Medicine, Sagamihara, Japan.
Department of Neurology, National Hakone Hospital, Odawara, Japan.
Department of Neurology, Tokai University School of Medicine, Isehara, Japan.

DOI: 10.4236/ijcm.2012.33038                

Abstract

We report a 50-year-old woman who developed localized proximal muscle weakness, in addition to transient elevation of antibodies to GM-1 ganglioside, without multifocal conduction block. She was treated with intravenous immunoglobulin (IVIg) and steroid pulse therapy, which were effective for over 10 years. Her clinical course and laboratory tests were consistent with lower motor neuron syndrome (LMNS) with localized proximal muscle weakness. We suggest that some patients diagnosed as LMNS may remain responsive to IVIg or steroid pulse therapy for a long time.

Keywords

Lower Motor Neuron Syndrome (LMNS); Multifocal Motor Neuropathy (MMN); Localized Proximal Muscle Weakness; Intravenous Immunoglobulin (IVIg); Anti-GM1 Ganglioside Antibody

Conflicts of Interest

The authors declare no conflicts of interest.

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