A Rapidly Progressive Proptosis, a Case Report


In contrast to intraocular metastases, orbital metastases are a rare manifestation of systemic malignancies; such orbital metastases account for only 1% - 13% of all orbital tumors. Such tumors grow rapidly; they may undergo necrosis, as the rate of tumor angiogenesis cannot keep pace with the rapidly expanding mass. Here, we report a rare case of an orbital metastasis from a nasopharyngeal carcinoma.

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A. Tajdini, M. Sinjab and S. Hassan, "A Rapidly Progressive Proptosis, a Case Report," Open Journal of Ophthalmology, Vol. 2 No. 2, 2012, pp. 37-39. doi: 10.4236/ojoph.2012.22009.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] S. M. Ahmad and B. Esmaeli, “Metastatic Tumors of the Orbit and Ocular Adnexa,” Current Opinion in Ophthalmology, Vol. 18, No. 5, 2007, pp. 405-413. doi:10.1097/ICU.0b013e3282c5077c
[2] C. C. Liaw, Y. S. Ho and K. K. Ng, “Nasopharyngeal Carcinoma Presenting as a Retro-Orbital Mass—Report of Three Cases,” Otolaryngology—Head and Neck Surgery, Vol. 103, No. 5, 1990, pp. 825-828.
[3] O. Oworu, P. Kyle and R. Morton, “Metastatic Esophageal Carcinoma Presenting as a Lacrimal Gland Tumour,” British Journal of Ophthalmology, Vol. 88, No. 7, 2004, pp. 972-973. doi:10.1136/bjo.2003.034322
[4] H. M. Moss, “Expanding Lesions of the Orbit. A Clinical Study of 230 Consecutive Cases,” American Journal of Ophthalmology, Vol. 54, 1962, pp. 761-770.
[5] J.-H. Yan and S. Gao, “Metastatic Orbital Tumors in Southern China during an 18-Year Period,” Graefe’s Archive for Clinical and Experimental Ophthalmology, Vol. 249, No. 9, 2011, pp. 1387-1393. doi:10.1007/s00417-011-1660-6
[6] S. Amrith, “Antero-Medial Orbital Masses Associated with Nasopharyngeal Carcinoma,” Singapore Medical Journal, Vol. 43, No. 2, 2002, pp. 97-99
[7] L. J. Old, E. A. Boyse, H. F. Oettgen, E. Dé-Harven, G. Geering, B. Williamson, et al., “Precipitating Antibody in Human Serum to an Antigen Present in Cultured Burkitt’s Lymphoma Cells,” Proceedings of the National Academy of Sciences of the USA, Vol. 56, No. 6, 1966, pp. 1699-1704. doi:10.1073/pnas.56.6.1699
[8] M. A. Vasef, A. Ferlito and L. M. Weiss, “Nasopharyngeal Carcinoma, with Emphasis on Its Relationship to Epstein-Barr Virus,” Annals of Otology, Rhinology and Laryngology, Vol. 106, No. 4, 1997, pp. 348-356.
[9] S. Secondino, M. Zecca, et al., “T-Cell Therapy for EBV-Associated Nasopharyngeal Carcinoma: Preparative Lymphodepleting Chemotherapy Does Not Improve Clinical Results,” Annals of Oncology, Vol. 23, No. 2, 2012, pp. 435-441.
[10] D. H Chara, T. Millerb and S. Kroll, “Orbital Metastases: Diagnosis and Course,” British Journal of Ophthalmology, Vol. 81, No. 5, 1997, pp. 386-390. doi:10.1136/bjo.81.5.386
[11] C. B. Luo, M. M. Teng, S. S. Chen, J. F. Lirng, W. Y. Guo and T. Chang, “Orbital Invasion in Nasopharyngeal Carcinoma: Evaluation with Computed Tomography and Magnetic Resonance Imaging,” Chinese Medical Journal (Taipei), Vol. 61, No. 7, 1998, pp. 382-388.
[12] K. D. Godeiro, A. N. Odashiro, D. N. Odashiro, B. F. Fernandes, M. N. Burnier, Jr, and S. Callejo, “Immuno-histochemical Panel of Undifferentiated Orbital Metastatic Carcinomas,” Orbit, Vol. 26, No. 2, 2007, pp. 101-106. doi:10.1080/01676830600977608
[13] A. P. Ferry and R. L. Font, “Carcinoma Metastatic to the Eye and the Orbit I: A Clinicopathologic Study of 227 Cases,” Archives of Ophthalmology, Vol. 92, No. 4, 1974, pp. 276-286. doi:10.1001/archopht.1974.01010010286003

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