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The effect of age, gender, level of adiposity and diabetes duration on glycated hemoglobin reduction after anti-diabetic therapy in type-2 diabetic patients

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DOI: 10.4236/jdm.2012.22039    4,688 Downloads   7,617 Views   Citations

ABSTRACT

Background: It is established that glycemic control measures involving diet and oral medication reduce glycated hemoglobin concentration (HbA1c) in type-2 diabetic patients. Aim: We aimed to determine whether HbA1c reduction after diabetic treatment is affected by age, gender, level of adiposity and diabetes duration in type-2 diabetic patients. Methods: One hundred and four type-2 diabetic patients participated in a 20-week diabetic control therapy involving oral medication (metformin) and lifestyle intervention (diet). We compared the HbA1c reduction after treatment between the elderly and non-elderly; males and females; overweight/obese and non-overweight/obese; and long-standing and newly diagnosed patients. Results: After the treatment, participants had mean HbA1c reduction of 1.1 ± 1.31% and weight loss of 2.46 ± 1.79 kg. Forty-six (44.2%) of the patients had acceptable HbA1c level of <6.5%. Significantly greater HbA1c reduction was observed in non-elderly, non-overweight/obese and newly diagnosed patients compared to the elderly, overweight/obese and long-standing diabetic patients (p < 0.05 or p < 0.01 or p < 0.001), respectively. HbA1c reduction did not indicate significant sex differences. Conclusion: The present findings suggest that treatment criteria for type-2 diabetes should account for the age, level of adiposity and diabetes duration of the patient in order to make optimal therapeutic decisions for the treatment of diabetes mellitus in adults.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

O. Ewenighi, C. , Dimkpa, U. , I. Adejumo, B. , C. Onyeanusi, J. , N. Nnatuanya, I. , Simon, U. , U. M. Onoh, L. and Ezeugwu, U. (2012) The effect of age, gender, level of adiposity and diabetes duration on glycated hemoglobin reduction after anti-diabetic therapy in type-2 diabetic patients. Journal of Diabetes Mellitus, 2, 245-250. doi: 10.4236/jdm.2012.22039.

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