A study of the levels of urinary microalbumin in non-diabetic normotensive obese individuals

D. Lad Hasit, K. C. Vasudha

Department of Biochemistry, M.S. Ramaiah Medical College, Bangalore, India.

DOI: 10.4236/abc.2012.22021                

Abstract

Diabetes mellitus, hypertension and obesity are associated with endothelial dysfunction. Microalbuminu-ria is an early sign of endothelial dysfunction. The occurrence of microalbuminuria in long standing diabetes mellitus and hypertension is well established. This study intends to find the occurrence of microal-buminuria in non-diabetic normotensive obese individuals. Objectives: To estimate urinary albumin creatinine ratio (UACR) in non-diabetic normotensive obese individuals. Design and Methods: 41 non- diabetic normotensive obese adults with Body Mass Index > 23 kg/m2 were taken as cases and 41 age and sex matched healthy non-obese adults with Body Mass Index < 23 kg/m2 were taken as controls. An-thropometric measurements (Body Mass Index and Waist circumference) and biochemical estimations (fasting blood glucose, lipid profile & spot urinary albumin creatinine ratio) were carried out. Results: urinary albumin creatinine ratio was lesser than the established microalbuminuric range of 30 - 300 mg/g, in both cases and controls irrespective of the values obtained for lipid profile and anthropometric indices. Conclusion: Microalbuminuria may not be present in obese patients without diabetes and/hypertension.

Keywords

Non-Diabetic Normotensive Obesity; Microalbuminuria; Cardiovascular Disease Risk

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Park, K. (2007) Non communicable diseases, textbook of preventive and social medicine. M/s Banarasidas Bhanot Publishers, Jabalpur, 332-336.
[2]	World Health Organisation. (2008) Fact sheet: Obesity and overweight. http://http://www.who.int/mediacentre/factsheets/fs311/en/print.html
[3]	Chudek, J., Adamczak, M., Nieszporek, T. and Wiêcek, A. (2006) The adipose tissue as an endocrine organ—A ne-phrologists perspective. Contrib Nephrol, 151, 70-90. doi:10.1159/000095320
[4]	Tijen, E.Y., Serdal, U. and Erkan, C., et al. (2007) Investigation of microalbuminuria in nondia-betic, normotensive obese women. The Japanese Society of Internal Me- dicine, 46, 1963-1965.
[5]	Yudkin, J.S., Forrest, R.D. and Jackson, C.A. (1988) Microalbuminuria as predictor of vascular disease in nondiabetic subjects. The Lancet, 2, 530-533. doi:10.1016/S0140-6736(88)92657-8
[6]	Alessia, F. and Leopoldo, R. (2005) Metabolic sydrome and endothelial dys-function. Current Hypertension Reports, 7, 88-95.
[7]	WHO/IASO/IOTF (2000) The Asia-Pacific perspective: Redefining obesity and its treatment. Health Communication, Melbourne.
[8]	(1990) Multicenter study of Tina-quant Albumin in urine and β-N-acetyl-glucosaminidase (β-NAG) in urine. Wien Klin Wochenschr, 103, 1-64.
[9]	Bartels, H. and Bohmer, M. (1971) Mi-cro-determination of creatinine. Clinica Chimica Acta, 32, 81-85.
[10]	Kunst, A., Drager, B. and Ziegenhorn, J. (1983) UV me- thods with hexokinase and glucose-6-phosphate dehy-dro-genase. In: Bergemeyer, H.Y., Ed., Methods of Enzymatic Analysis, Vol VI, Verlag Chemie, Deerfield, 163-172.
[11]	Stadtman, T.C. (1957) [63] Preparation and assay of cholesterol and ergosterol. Methods in Enzymology, 3, 392- 394. doi:10.1016/S0076-6879(57)03403-5
[12]	Seidel, J., et al. (1993) AACC Meeting extract 34. Clinical Chemistry, 39, 1127.
[13]	Sugiuchi, H., Uji, Y., Okabe, H. and Irie, T., et al. (1995) Direct measurement of high-density lipoprotein in cho-lesterol in serum with polyethylene GLYCOL-modified en-zymes and sulfated α-Cyclodextrin. Clinical Chemistry, 41, 717-723.
[14]	Friedwald, W.T., Levy, R.I., Fredrickson, D.S., et al. (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of preparative ultracen-trifuge. Clinical Chemistry, 18, 499-502.
[15]	Valensi, P., Assayag, M. and Busby, M., et al. (1996) Microalbuminuria in obese patients with or without hypertension. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity, 20, 20574- 20579.
[16]	Garg, J.P. and Bakris, G.L. (2002) Microal-buminuria: Marker of vascular dysfunction, risk factor for car-diovascular disease. Vascular Medicine, 7, 35-43. doi:10.1191/1358863x02vm412ra
[17]	Romundstad, S., Hol-men, J., Kvenild, K., Hallan, H. and Ellekjaer, H. (2003) Microalbuminuria and all cause mortality in 2,089 apparently healthy individuals: A 4.4-year follow-up study. The Nord-Trondelag Health Study (HUNT), Norway. American Journal of Kidney Diseases, 42, 466- 473. doi:10.1016/S0272-6386(03)00742-X
[18]	Naidoo, D.P. (2002) The link between microalbuminuria,endothelial dysfunction and cardiovascular disease in diabetes. Cardiovascular Journal of Africa, 13, 194-199.
[19]	Arnlov, J., Evans, J.C. and Meigs, J.B., et al. (2005) Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondia-betic individuals: The framinghan heart study. Circulation, 112, 969- 975. doi:10.1161/CIRCULATIONAHA.105.538132