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Unusual spontaneous improvement in Asian variant of intravascular large B-cell lymphoma

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DOI: 10.4236/ojim.2012.21004    3,356 Downloads   5,452 Views   Citations

ABSTRACT

The clinical course of the Asian variant of intravascular large B-cell lymphoma (AIVL) is generally very aggressive. We describe a case of AIVL demonstrating an unusual clinical course, with spontaneous improvement. An 81-year-old man with high-grade fever and thrombocytopenia was admitted to our hospital. Although we could not confirm the origin of his symptoms, they disappeared completely without intervention within 2 weeks. Three months later, however, thrombocytopenia reappeared and progressed. Finally, he was readmitted due to a subdural hemorrhage with high fever and he finally died of rapidly progressive multiple organ failure. Autopsy findings revealed the presence of B-cell lymphoma cells in microscopic vessels of many organs as well as hemophagocytosis in the bone marrow. He was diagnosed with AIVL with an unusual indolent clinical course with spontaneous improvement.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Ninomiya, T. , Nakamura, T. , Fujii, N. , Hiraki, A. , Umemura, S. , Yamane, H. , Shirakawa, A. and Kamei, H. (2012) Unusual spontaneous improvement in Asian variant of intravascular large B-cell lymphoma. Open Journal of Internal Medicine, 2, 15-18. doi: 10.4236/ojim.2012.21004.

References

[1] Murase, T., Yamaguchi, M., Suzuki, R., Okamoto, M., Sato, Y., Tamaru, J., Kojima, M., Miura, I., Mori, N., Yoshino, T. and Nakamura, S. (2007) Intravascular large b-cell lymphoma (ivlbcl): A clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of cd5. Blood, 109, 478-485. doi:10.1182/blood-2006-01-021253
[2] Murase, T. and Nakamura, S. (1999) An Asian variant of intravascular lymphomatosis: An updated review of malignant histiocytosis-like b-cell lymphoma. Leukemia and Lymphoma, 33, 459-473.
[3] Murase, T., Nakamura, S., Kawauchi, K., Matsuzaki, H., Sakai, C., Inaba, T., Nasu, K., Tashiro, K., Suchi, T. and Saito, H. (2000) An Asian variant of intravascular large b-cell lymphoma: Clinical, pathological and cytogenetic approaches to diffuse large b-cell lymphoma associated with haemophagocytic syndrome. British Journal of Haematology, 111, 826-834. doi:10.1046/j.1365-2141.2000.02426.x
[4] Murase, T., Nakamura, S., Tashiro, K., Suchi, T., Hiraga, J., Hayasaki, N., Kimura, M., Murakami, M., Mizoguchi, Y., Suzuki, T. and Saito, H. (1997) Malignant histiocytosis-like b-cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: A report of five cases and review of the literature. British Journal of Haematology, 99, 656-664. doi:10.1046/j.1365-2141.1997.4623265.x
[5] Ishiko, J., Mizuki, M., Yasumi, M., Ujiie, H., Nakamichi, I., Aozasa, K. and Kanakura, Y. (2007) An indolent subtype of “Intravascular lymphoma”: A case with a 3-year history of ldh elevation. Leukemia and Lymphoma, 48, 1872-1874. doi:10.1080/10428190701493936
[6] Nakao, N., Yoshida, M., Iwata, M., Hashizume, Y. and Sahashi, K. (2008) A case of intravascular malignant lymphomatosis presenting as slowly progressive paraplegia. Brain Nerve, 60, 181-185.
[7] Sekine, A., Hagiwara, E., Okudera, K., Baba, T. and Ogura, T. (2009) A case of slowly progressive intravascular lymphoma with respiratory failure caused by diffuse pulmonary vasoconstriction. Nihon Kokyuki Gakkai Zasshi, 47, 924-929.
[8] Asada, N., Odawara, J., Kimura, S., Aoki, T., Yamakura, M., Takeuchi, M., Seki, R., Tanaka, A. and Matsue, K. (2007) Use of random skin biopsy for diagnosis of intravascular large b-cell lymphoma. Mayo Clinic Proceedings, 82, 1525-1527. doi:10.4065/82.12.1525

  
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