Relevance of Economic Field Microscope in Remote Rural Regions for Concurrent Observation of Malaria & Inflammation

Deepak Bhattacharya

Fight Malaria at Home, C/o Sri Radha Krishna, Bhubaneswar, India.

DOI: 10.4236/aid.2012.21003                

Abstract

Based on mono station use for >12 continuous years (since 1998) in drug resistant core endemic region, India, anti-inflammatory effect on WBC is demonstrated using a simple; economic monocular microscope that can be used out in the open—using day light/lamp. Is infinitely helpful for rural clinicians and the administrations, in developing nations. Although indispensable, a field microscope has become expensive; is in short supply; there is a crying need in the rural and the remote.

Keywords

OMARIA; Field Microscopy; Inflammation Observation; WBC Architecture Alteration; Gametocydal; Plasmocidal

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	N. Dhingra, P. Jha, V. P. Sharma, A. A. Cohen, R. M. Jotkar, P. S. Rodriguez, et al., “Adult and Child Malaria Mortality in India: A Nationally Representative Mortality Survey,” Lancet, Vol. 376, No. 9754, 2010, pp. 1768-1774. doi:10.1016/50140-6736(10)60831-8
[2]	K. M. Prashant, J. Hema, V. Neena, K. S. Surya, E. Alex, M. B. Rajendra, C. S. Harish, L. S. Patrick, P. D. Aditya and K. B. Virendra, “Mutant pfcrt ‘SVMNT’ Haplotype and Wild Type Pfmdr1 ‘N86’ Are Endemic in Plasmodium vivax Dominated Areas of India under High Chloroquine Exposure,” Malaria Journal, Vol. 11, 2012, p. 16. doi:10.1186/1475-2875-11-16
[3]	P. Nageshwar, “India Claims Malaria Cure,” BBC, 2000. http://news.bbc.co.uk/2/hi/south_asia/988316.stm
[4]	Z. Tekeste, M. Workineh and B. Petros, “Comparison of Paracheck Pf Test with Conventional Light Microscopy for the Diagnosis of Malaria in Ethiopia,” Asian Pacific Journal of Tropical Disease, Vol. 1, No. 3, 2012, pp. 1-3.
[5]	UNICEF-White House Summit on Malaria, New York, 2006. http://www.unicef.org/health/index_37773.html
[6]	President’s Malaria Initiative. http://georgewbush-whitehouse.archives.gov/infocus/malaria/
[7]	Bill & Milinda Gates Foundation, Grand Challenges in Global Health. http://www.grandchallenges.org/explorations/Pages/introduction.aspx
[8]	D. Bhattacharya, “Fight Malaria at Home,” Express Pharma, Bombay, 1-15 May 2006. pp. 1-15. http://www.expresspharmaonline.com/20060515/research02.shtml
[9]	J. B. Lekana-Douki, S. D. Dinzouna Boutamba, R. Zatra, S. E. Zang Edou, H. Ekomy, U. Bisvigou and F. S. Toure-Ndouo “Increased Prevalence of the Plasmodium falciparum Pfmdr1 86N Genotype among Field Isolates from Franceville, Gabon after Replacement of Chloroquine by Artemether Lumefantrine and Artesunate-Mefloquine,” Infection, Genetics and Evolution, Vol. 11, No. 2, 2011, pp. 512-517. doi:10.1016/j.meegid.2011.01.003
[10]	D. Bhattacharya, “OMARIA—A New Herbal Anti Malarial,” The Pharma Review, Vol. 1, No. 1, 2002, pp. 80-84.
[11]	H. Nagaset and J. F. Woessner, “Matrix Metalloprotinases,” Journal of Biological Chemistry, Vol. 274, No. 31, 1999, pp. 21491-21494.
[12]	M. Prato and G. Giribaldi, “Matrix Metalloproteinase-9 and Hemozoin: Wedding Rings for Human Host and Pf Parasite in Complicated Malaria,” Journal of Tropical Medicine, Vol. 2011, 2011, p. 6. doi:10.1155/2011/628438
[13]	D. Bhattacharya, “A New Anti-Malarial Cum Wide Spectrum Anti-Viral: Integrated Approach for Whole Village Comprehensive Cure Cum Prevention,” In: S. N. Patro, Ed., 9th Orissa Science Congress, Bhubaneswar, December 2005, pp. 76-84.
[14]	S. Toovey and A. Jamieson, “Audiometric Changes (Neurotoxicity) Associated with the Treatment of Uncomplicated Falciparum Malaria with Co-Artemether,” Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 98, No. 5, 2004, pp. 261-267.
[15]	D. Bhattacharya, “Fight Malaria at Home,” Asian Pacific Journal of Tropical Diseases, Vol. 1, No. 2, 2011, pp. 142-149.
[16]	M. Dell’Agli, G. V. Galli, Y. Corbett, D. Taramelli, L. Lucantoni, A. Habluetzel, O. Maschi, D. Caruso, F. Giavarini, S. Romeo, D. Bhattacharya and E. Bossisio, “Antiplasmodial Activity of Punica granatum L. Fruit Rind,” Journal of Ethnopharmacology, Vol. 125, No. 2, 2009, pp. 279-285. doi:10.1016/j.jep.2009.06.025
[17]	M. Dell’Agli, G. V. Galli, M. Bulgari, N. Basilico, S. Romeo, D. Bhattacharya, D. Taramelli and E. Bosisio, “Ellagitannins of the Fruit Rind of Pomegranate (Punica granatum) Antagonize in Vitro the Host Inflammatory Response Mechanisms Involved in the Onset of Malaria,” Malaria Journal, Vol. 9, 2010, p. 208. doi:10.1186/1475-2875-9-208
[18]	J. B. Lekana-Douki, D. Bhattacharya, R. Zatra and S. T.-N. Fousseyni, “Indian Anti-Malaria OMARIA Is Effective against African Drug Resistant P. falciparum Field Isolates and Laboratory Strains; without Toxicity,” International Journal of Clinical Medicine, Vol. 3, No. 1, 2012, pp. 1-8. doi:10.4236/ijcm.2012.31001
[19]	W. S. Akhwale, J. K. Lum, A. Kaneko, H. Eto, C. Obonyo, A. Bjorkman and T. Kobayakawa, “Anemia and Malaria at Different Altitudes in the Western Highlands 0f Kenya,” Acta Tropica, Vol. 91, No. 2, 2004, pp. 167-175. doi:10.1016/j.actatropica.2004.02.010
[20]	C. R. J. C. Newton, T. T. Hien and N. White, “Cerebral Malaria,” Journal of Neurology, Neurosurgery & Psychiatry, Vol. 69, 2000, pp. 433-441. doi:10.1136/jnnp.69.4.433
[21]	R. Idro, N. E. Jenkins, C. R. J. C. Newton, “Pathogenesis, Clinical Features, and Neurological Outcome of Cerebral Malaria,” Lancet Neurology, Vol. 4, No. 12. 2005, pp. 827-840. doi:10.1016/S1474-4422(05)70247-7
[22]	J. T. Bousema, L. C. Gouagna, C. J. Drakeley, A. M. Meutstege, B. A. Okech, I. N. J. Akim, J. C. Beier, J. I. Githure and R. W. Sauerwein, “Plasmodium falciparum Gametocyte Carriage In Asymptomatic Children in Western Kenya,” Malaria Journal, Vol. 3, 2004, p. 18. doi:10.1186/1475-2875-3-18
[23]	C. L. Peatey, D. Leroy, D. L. Gardiner and K. R Trenholme, “Anti-Malarial Drugs: How Effective Are They against Plasmodium falciparum Gametocytes?” Malaria Journal, Vol. 11, 2012, p. 34. doi:10.1186/1475-2875-11-34
[24]	D. Tagliasacchi and G. Carboni, “Drawings of Michele Pirazzini,” Translation by David W. Walker, 1997. http://www.funsci.com/fun3_en/blood/blood.htm#23
[25]	E. M. W. Billig, W. P. O’Meara, E. M. Riley and F. E. McKenzie, “Developmental Allometry And Paediatric Malaria,” Malaria Journal, Vol. 11, 2012, p. 64
[26]	L. Veronic and P. Karanis, “Malaria Vaccine: Looking Back and Lessons Learnt,” Asian Pacific Journal of Tropical Biomedicine, Vol. 1, No. 1, 2011, pp. 74-78. doi:10.1016/S2221-1691(11)60072-5
[27]	L. Schwartz, G. V. Brown, B. Genton and V. S. Moorthy, “A Review of Malaria Vaccine Clinical Projects Based on the WHO Rainbow Table,” Malaria Journal, Vol. 11, 2012, p. 11. doi:10.1186/1475-2875-11-11
[28]	Multilateral Initiative on Malaria. http://www.mimalaria.org/eng/historyandevolution.asp
[29]	World Health Organization, “Sixty-first World Health Assembly,” WHO, Geneva, 2008. http://www.rbm.who.int/.
[30]	S. J. Ameh, O. O. Obiageri, B. C. Peace and G. S. Karnuis, “Medical Herbalism and Herbal Clinical Research: A Global Perspective,” British Journal of Pharmaceutical Research, Vol. 1, No. 4, 2011, pp. 99-123.