Synthesis and in vitro antibacterial evaluation of some thiosemicarbazides and thiosemicarbazones


In the present study various thiosemicarbazides and thiosemicarbazones were synthesized and screened for their antimicrobial activity. Among the ligands tested, compounds 1, 3, 4 and 5 demonstrated inhibitory effects at 0.4 - 0.5 μM concentrations against E. coli while 1-(4-fluorobenzoyl)-N4-ethyl-thiosemicar-bazide (3) demonstrated the maximum inhibitory effective compound against E. coli, also possessing high water solubility. Instead, compound 3 demonstrated weak antibiotic effects against S. aurous while compounds 4 - 6 demonstrated significant antibacterial effects at 0.4 - 0.42 μM against the latter organism. Chloramphenicol was used as the positive control.

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Sheikhy, M. , Jalilian, A. , Novinrooz, A. and Motamedi-Sedeh, F. (2012) Synthesis and in vitro antibacterial evaluation of some thiosemicarbazides and thiosemicarbazones. Journal of Biomedical Science and Engineering, 5, 39-42. doi: 10.4236/jbise.2012.52006.

Conflicts of Interest

The authors declare no conflicts of interest.


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