Some No Longer Unknowns in Science
Arieh Ben-Naim
.
DOI: 10.4236/ojbiphy.2012.21001   PDF    HTML   XML   5,402 Downloads   12,784 Views   Citations

Abstract

Three out of 125 “big questions of science”, can now be claimed to have been answered. All of these questions involve water; its structure, its role in protein folding and its role in protein-protein association.

Share and Cite:

A. Ben-Naim, "Some No Longer Unknowns in Science," Open Journal of Biophysics, Vol. 2 No. 1, 2012, pp. 1-3. doi: 10.4236/ojbiphy.2012.21001.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] D. Kennedy and C. Norman, “What Don’t We Know?” Science, Vol. 309, No. 5731, 2005, p. 75. doi:10.1126/science.309.5731.75
[2] A. Ben-Naim, “Molecular Theory of Water and Aqueous Solutions, Part I: Understanding Water,” World Scientific, Singapore, 2009. doi:10.1142/9789812837615
[3] A. Ben-Naim, “Molecular Theory of Water and Aqueous Solutions: Part II The Role of Water in Protein Folding Self Assembly and Molecular Recognition,” World Scientific, Singapore, 2011.
[4] C. Levinthal, “Are There Pathways for Protein Folding,” Journal de Chimie Physique, Vol. 65, No. 1, 1968, pp. 44-45.
[5] C. Levinthal, “Mossbauer Spectroscopy in Biological Systems,” J. T. P. De Brunner and E. Munck, Eds., University of Illinois Press, 1969, pp. 22-24.
[6] C. B. Anfinsen, “Principles that Govern the Folding of Protein Chains,” Science, Vol. 181, No. 4096, 1973, pp. 223-230. doi:10.1126/science.181.4096.223
[7] A. Ben-Naim, “Pitfalls in Anfinsen’s Thermodynamic Hypothesis,” Chemical Physics Letters, Vol. 511, No. 1-3, 2011, pp. 126-128. doi:10.1016/j.cplett.2011.05.049
[8] R. Zwanzig, A. Szabo and B. Bagchi, “Levinthal’s Paradox,” Proceedings of the National Academy of Science, Vol. 89, No. 1, 1992, pp. 20-22. doi:10.1073/pnas.89.1.20
[9] W. Kauzmann, “Some Factors in the Interpretation of Protein Denaturation,” Advances in Protein Chemistry, Vol. 14, 1959, pp. 1-63. doi:10.1016/S0065-3233(08)60608-7
[10] A. Ben-Naim, “Strong Forces between Hydrophilic Macromolecules; Implications in Biological Systems,” Journal of Chemical Physics, Vol. 93, No, 25, 1991, pp. 8196- 8210.
[11] A. Ben-Naim, “Solvent Effects on Protein Association and Protein Folding,” Biopolymers, Vol. 29, No. 3, 1990, pp. 567-596. doi:10.1002/bip.360290312
[12] A. Ben-Naim, “Molecular Recognition-Viewed Through the Eyes of the Solvent,” Biophysical Chemistry, Vol. 101-102, No. 10, 2002, pp. 309-319. doi:10.1016/S0301-4622(02)00165-5
[13] A. Ben-Naim, “On the Driving Forces for Protein-Protein Association,” Journal of Chemical Physics, Vol. 125, No, 2, 2006, pp. 1-10.
[14] H. Wang and A. Ben-Naim, “Solvation and Solubility of Globular Proteins,” Journal of Physical Chemistry B, Vol. 101, No, 6, 1997, pp. 1077-1086. doi:10.1021/jp961591b

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.