Acute encephalopathy with biphasic seizures and late reduced diffusion associated with Epstein-Barr virus
Nobuyuki Nosaka, Yoshinori Ito, Shinya Hara
DOI: 10.4236/ojped.2011.14017   PDF   HTML     5,622 Downloads   8,976 Views  


We report the case of a 12 month-old female diagnosed with acute encephalopathy with biphasic seizures and late reduced diffusion. Epstein-Barr virus DNA was detected in both cerebrospinal fluid (511 copies/mL) and in serum (828 copies/mL) during the early stage of disease, suggesting a role for this virus in pathogenesis.

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Nosaka, N. , Ito, Y. and Hara, S. (2011) Acute encephalopathy with biphasic seizures and late reduced diffusion associated with Epstein-Barr virus. Open Journal of Pediatrics, 1, 72-74. doi: 10.4236/ojped.2011.14017.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Takanashi, J., Oba, H., Barkovich, A.J., et al. (2006) Diffusion MRI abnormalities after prolonged febrile seizures with encephalopathy. Neurology, 66, 1304-1309. doi:10.1212/01.wnl.0000210487.36667.a5
[2] Maegaki, Y., Kondo, A., Okamoto, R., et al. (2006) Clinical characteristics of acute encephalopathy of obscure origin: A biphasic clinical course is a common feature. Neuropediatrics, 37, 269-277. doi:10.1055/s-2006-955928
[3] Okamoto, R., Fujii, S., Inoue, T., et al. (2006) Biphasic clinical course and early white matter abnormalities may be indicators of neurological sequelae after status epilepticus in children. Neuropediatrics, 37, 32-41. doi:10.1055/s-2006-923949
[4] Yamanouchi, H., Kawaguchi, N., Mori, M., et al. (2006) Acute infantile encephalopathy predominantly affecting the frontal lobes. Pediatric Neurology, 34, 93-100. doi:10.1016/j.pediatrneurol.2005.08.002
[5] Takanashi, J., Tsuji, M., Amemiya, K., Tada, H. and Barkovich, A.J. (2007) Mild influenza encephalopathy with biphasic seizures and late reduced diffusion. Journal of the Neurological Sciences, 256, 86-89. doi:10.1016/j.jns.2007.02.006
[6] Okumura, A., Kidokoro, H., Tsuji, T., et al. (2009) Differences of clinical manifestations according to the patterns of brain lesions in acute encephalopathy with reduced diffusion in the bilateral hemispheres. American Journal of Neuroradiology, 30, 825-830. doi:10.3174/ajnr.A1431
[7] Bale, J.F. (1999) Human herpesviruses and neurological disorders of childhood. Seminars in Pediatric Neurology, 6, 278-287. doi:10.1016/S1071-9091(99)80026-6
[8] Doja, A., Bitnun, A., Ford Jones, E.L., et al. (2006) Pediatric Epstein-Barr virus-associated encephalitis: 10-year review. Journal of Child Neurology, 21, 384-391.
[9] Domachowske, J.B., Cunningham, C.K. and Cummings, D.L. (1996) Acute manifestations and neurologic sequelae of Epstein-Barr virus encephalitis in children. Pediatric Infectious Disease Journal, 15, 871-875. doi:10.1097/00006454-199610000-00008
[10] Shian, W.J. and Chi, C.S. (1996) Epstein-Barr virus encephalitis and encephalomyelitis: MR findings. Pediatric Radiology, 26, 690-693. doi:10.1007/BF01356839

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