Temperature and Magnetic Resonance Characteristics of Zinc, Manganese, Gadolinium, Gold, Iron Magnetic Nanoparticles and Cytokine Synergy in Hyperthermia

Saleh S. Hayek, Rakesh Sharma, Soonjo Kwon, Avdhesh Sharma, Ching J.Chen

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Center for Nanomagnetics and Biotechnology, Florida State University, Tallahassee.
Center for Nanomagnetics and Biotechnology, Florida State University, Tallahassee, FL.
Department of Biological Engineering, Utah State University, Logan, UT 84322..
Nanotechnology Division, Electrical Engineering Department, MP University of Agriculture and Technology, Udaipur, Rajasthan, India.

DOI: 10.4236/jbise.2008.13031                

Abstract

The temperature and magnetic moment depend-ence for assessing localized heating utilizing a new class of Manganese-Zinc-Gadolinium mag-netic nanoparticles was studied. These particles showed heating effect when subjected to alter-nating filed. Alternatively, a new approach was used to get disperse heating without spot heating by using the synthesis of particles at controlled Curie temperature of less than 44oC. The study reports a simple synthesis of Mn0.5Zn0.5GdxFe(2-x)O4 nanoparticles using chemical co- precipita-tion technique. The particles exhibited Curie temperature of 42篊 and high magnitude of mag-netic moments. The particles showed sigmoid behavior of dependence between temperature and magnetic moments. The Nuclear Magnetic Resonance spectroscopy showed T1 depend-ence on temperature in the range of 10-45篊. The particles may have high promise for self con-trolled magnetic hyperthermia application and its monitoring.

Keywords

hyperthermia, nanoparticles, tempera-ture imaging

Conflicts of Interest

The authors declare no conflicts of interest.

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