Share This Article:

Which stressors are responsible for the worsening in the clinical symptomatology of lupus?

Abstract Full-Text HTML Download Download as PDF (Size:227KB) PP. 313-319
DOI: 10.4236/health.2009.14051    4,934 Downloads   8,624 Views   Citations


Objective: The purpose of this study was to test which stressors worsen the symptoms perceived by patients with lupus, thus broadening and corroborating results obtained in a previous study published in Psychosomatic Medicine. Methods: In order to examine this question, we selected 43 patients with lupus whose symp-toms worsened due to the effects of daily stress. These patients were divided into two groups: patients whose increase in clinical lupus symp-tomatology was predicted by an increase in daily stressors on the same day (G1) and pa-tients whose increase in clinical lupus symp-tomatology was predicted by an increase in daily stressors the day before and the same day (G2). Later, three factorial analyses were con-ducted with the items related to stressors and the items related to lupic symptoms. Results: The results showed that in G1 there were three factors that made up a total of 35.08% of the explained variance. The stressors associated with certain symptoms of the illness in this group are feeling ill or being worried about their physical appearance, with the main stressor being the illness itself. However, in G2, two factors were found that made up a total of 40.37% of the explained variance for lag=0 and 38.67% for lag=1. The stressors associated with the majority of the lupus symptoms are of an interpersonal and work-related nature. This as-sociation was maintained when we carried out the factorial analyses with the items of the symptoms from the following day. Conclusions: The interpersonal and work-related stressors are related to a worsening in the majority of the lupic symptoms in the patients whose sympto-matology worsens as a result of daily stress experienced the day before.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Peralta-Ramírez, M. , Jiménez-Alonso, J. and Pérez-García, M. (2009) Which stressors are responsible for the worsening in the clinical symptomatology of lupus?. Health, 1, 313-319. doi: 10.4236/health.2009.14051.


[1] Herrmann, M., Scholmerich, J., and Straub, R.H. (2000) Stress and rheumatic diseases. Rheum Dis. Clin. North Am., 26, 737-63.
[2] Adams, S.J., Dammers, P.M., Saia, T.L., et al. (1994) Stress, depression and anxiety predict average symptom severity and daily symptom fluctuation in systemic lupus erythematosus. J Behav. Med., 17, 459-477.
[3] Wekking, E.M., Vingerhoets, A.J., Van Dam, A.P., et al. (1991) Daily stressors and systemic lupus erythematosus: A longitudinal analyses-first findings. Psychother Psy-chosom, 55,108-113.
[4] Schubert, C., Lampe, A., Rumpold, G., et al. (1999) Daily psychosocial stressors interfere with the dynamics of urine neopterin in a patient with systemic lupus erythe-matosus: An integrative single-case study. Pychosom Med, 61, 876-882.
[5] Da costa, D., Dobkin, P., Pinard, L., et al. (1999) The role of stress in functional disability among women with sys-temic lupus erythematosus: A prospective study. Arthritis Care and Research, 12, 112-119.
[6] Schubert, C., Lampe, A., Geser, W., et al. (2003) Daily psychosocial stressors and cyclic response patterns in urine cortisol and neopterin in a patient with systemic lupus erythematosus. Psychoneuroendocrinology, 28, 459-473.
[7] Pawlak, C., Witte, T., Heiken, H., et al. (2003) Flares in patients with systemic lupus erythematosus is associated with daily psychological stress. Psychother Psychosom, 72, 159-165.
[8] Peralta-Ramirez, M.I., Jimenez-Alonso, J., Godoy-Garcia, J.F., and Perez-Garcia, M. (2004) The effects of daily stress and stressful life events on the clinical symptoma-tology of patients with lupus erythematosus. Psychosom Med., 66, 788-94.
[9] Tan, E.M., Cohen, A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N., and Win-chester, R.J. (1982) The revised criteria for the classifica-tion of systemic lupus erythematosus. Arthritis Rheum, 25, 1271-7.
[10] Peralta, M.I., López, F., Godoy, J.F., Godoy, D., Sánchez, M.B., and Pérez, M. (2002) Validación de la detección de cambio del inventario de estrés cotidiano. Psicología Conductual, 10, 343-354.
[11] Peralta-Ramírez, M.I., Verdejo García, A., Mu?oz, M.A., Sabio Sánchez, J.M., Jiménez-Alonso, J., and Pérez García, M. (2007) Lupus symptoms inventory (LSI): Develop-ment and validation of a self-evaluation inventory of the subjective symptoms of systemic lupus erythematosus. Journal of Clinical Psychology in Medical Settings, 344-350.
[12] Greco, C.M., Rudy, T.E., and Manzi, S. (2004) Effects of a stress-reduction program on psychological function, pain, and physical function of systemic lupus erythema-tosus patients: A randomized controlled trial. Arthritis Rheum, 15, 625-34.
[13] Haupt, M., Millen, S., Janner, M., et al. (2005) Improve-ment of coping abilities in patients with systemic lupus erythematosus: A prospective study. Ann Rheum Dis., 64, 1618-1623.
[14] Peralta-Ramírez, M.I., Robles-Ortega, H., Navarrete- Navarrete, N., and Jiménez-Alonso, J.F. (2009) Aplicación de la terapia de afrontamiento del estrés en dos poblaciones con alto estrés: Pacientes crónicos y personas sanas.

comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.