[1]
|
Santos, R., Ursu, O., Gaulton, A., et al. (2017) A Comprehensive Map of Molecular Drug Targets. Nature Reviews Drug Discovery, 16, 19-34. https://doi.org/10.1038/nrd.2016.230
|
[2]
|
Sriram, K. and Insel, P.A. (2018) G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? Molecular Pharmacology, 93, 251-258. https://doi.org/10.1124/mol.117.111062
|
[3]
|
Kshatri, A.S., Gonzalez-Hernandez, A. and Giraldez, T. (2018) Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System. Frontiers in Molecular Neuroscience, 11, 258. https://doi.org/10.3389/fnmol.2018.00258
|
[4]
|
Yang, H., Zhang, G. and Cui, J. (2015) BK Channels: Multiple Sensors, One Activation Gate. Frontiers in Physiology, 6, 29. https://doi.org/10.3389/fphys.2015.00029
|
[5]
|
Adelman, J.P., Shen, K.Z., Kavanaugh, M.P., et al. (1992) Calcium-Activated Potassium Channels Expressed from Cloned Complementary DNAs. Neuron, 9, 209-216. https://doi.org/10.1016/0896-6273(92)90160-F
|
[6]
|
Pantazis, A. and Olcese, R. (2016) Biophysics of BK Channel Gating. International Review of Neurobiology, 128, 1-49. https://doi.org/10.1016/bs.irn.2016.03.013
|
[7]
|
Lee, U.S. and Cui, J. (2010) BK Channel Activation: Structural and Functional Insights. Trends in Neurosciences, 33, 415-423. https://doi.org/10.1016/j.tins.2010.06.004
|
[8]
|
Zhang, G., Huang, S.Y., Yang, J., et al. (2010) Ion Sensing in the RCK1 Domain of BK Channels. Proceedings of the National Academy of Sciences of the United States of America, 107, 18700-18705. https://doi.org/10.1073/pnas.1010124107
|
[9]
|
Esser, M., Guy Jr., G., Zhang, K. and Brewer, R. (2019) Binge Drinking and Prescription Opioid Misuse in the US, 2012-2014. American Journal of Preventive Medicine, 57, 197-208. https://doi.org/10.1016/j.amepre.2019.02.025
|
[10]
|
Chen, L., Jeffries, O., Rowe, I.C.M., et al. (2010) Membrane Trafficking of Large Conductance Calcium-Activated Potassium Channels Is Regulated by Alternative Splicing of a Transplantable, Acidic Trafficking Motif in the RCK1-RCK2 Linker. Journal of Biological Chemistry, 285, 23265-23275. https://doi.org/10.1074/jbc.M110.139758
|
[11]
|
Wu, Y., Yang, Y., Ye, S. and Jiang, Y. (2010) Structure of the Gating Ring from the Human Large-Conductance Ca2+-Gated K+ Channel. Nature, 466, 393-397. https://doi.org/10.1038/nature09252
|
[12]
|
Ishii, T.M., Maylie, J. and Adelman, J.P. (1997) Determinants of Apamin and d-Tubocurarine Block in SK Potassium Channels. Journal of Biological Chemistry, 272, 23195-23200. https://doi.org/10.1074/jbc.272.37.23195
|
[13]
|
Griguoli, M., Sgritta, M. and Cherubini, E. (2016) Presynaptic BK Channels Control Transmitter Release: Physiological Relevance and Potential Therapeutic Implications. The Journal of Physiology, 594, 3489-3500. https://doi.org/10.1113/JP271841
|
[14]
|
Gonzalez-Perez, V. and Lingle, C.J. (2019) Regulation of BK Channels by Beta and Gamma Subunits. Annual Review of Physiology, 81, 113-137. https://doi.org/10.1146/annurev-physiol-022516-034038
|
[15]
|
Contet, C., Goulding, S.P., Kuljis, D.A. and Barth, A.L. (2016) BK Channels in the Central Nervous System. International Review of Neurobiology, 128, 281-342. https://doi.org/10.1016/bs.irn.2016.04.001
|
[16]
|
Ramírez-Latorre, J.A. (2012) Functional Upregulation of Ca2+-Activated K+ Channels in the Development of Substantia Nigra Dopamine Neurons. PLoS ONE, 7, e51610. https://doi.org/10.1371/journal.pone.0051610
|
[17]
|
Selemon, L.D. (2013) A Role for Synaptic Plasticity in the Adolescent Development of Executive Function. Translational Psychiatry, 3, e238. https://doi.org/10.1038/tp.2013.7
|
[18]
|
Lo, E.H., Dalkara, T. and Moskowitz, M.A. (2003) Mechanisms, Challenges and Opportunities in Stroke. Nature Reviews Neuroscience, 4, 399-415. https://doi.org/10.1038/nrn1106
|
[19]
|
Gribkoff, V.K., Starrett Jr., J.E., Dworetzky, S.I., et al. (2001) Targeting Acute Ischemic Stroke with a Calcium-Sensitive Opener of Maxi-K Potassium Channels. Nature Medicine, 7, 471-477. https://doi.org/10.1038/86546
|
[20]
|
Jensen, B.S. (2002) BMS-204352: A Potassium Channel Opener Developed for the Treatment of Stroke. CNS Drug Reviews, 8, 353-360. https://doi.org/10.1111/j.1527-3458.2002.tb00233.x
|
[21]
|
Koide, M., Bonev, A.D., Nelson, M.T. and Wellman, G.C. (2012) Inversion of Neurovascular Coupling by Subarachnoid Blood Depends on Large-Conductance Ca2+-Activated K+ (BK) Channels. Proceedings of the National Academy of Sciences of the United States of America, 109, E1387-1395. https://doi.org/10.1073/pnas.1121359109
|
[22]
|
Yi, M., Wei, T., Wang, Y., et al. (2017) The Potassium Channel KCa3.1 Constitutes a Pharmacological Target for Astrogliosis Associated with Ischemia Stroke. Journal of Neuroinflammation, 14, Article No. 203. https://doi.org/10.1186/s12974-017-0973-8
|
[23]
|
Li, L., Li, S., Hu, C., et al. (2019) BKCa Channel Is a Molecular Target of Vitamin C to Protect against Ischemic Brain Stroke. Molecular Membrane Biology, 35, 9-20. https://doi.org/10.1080/09687688.2019.1608378
|
[24]
|
Del Rio, D., Agnoli, C., Pellegrini, N., et al. (2011) Total Antioxidant Capacity of the Diet Is Associated with Lower Risk of Ischemic Stroke in a Large Italian Cohort. The Journal of Nutrition, 141, 118-123. https://doi.org/10.3945/jn.110.125120
|
[25]
|
Rottgen, T., Dick, G., Chantler, P. and Frisbee, J. (2016) Increased Function of Large-Conductance of Potassium Channels following Acute Ischemic Stroke. The FASEB Journal, 30, 1224.
|
[26]
|
Szteyn, K. and Singh, H. (2020) BKCa Channels as Targets for Cardioprotection. Antioxidants (Basel), 9, 760. https://doi.org/10.3390/antiox9080760
|
[27]
|
Wang, Y.J., Sung, R.J., Lin, M.W. and Wu, S.N. (2006) Contribution of BKCa-Channel Activity in Human Cardiac Fibroblasts to Electrical Coupling of Cardiomyocytes-Fibroblasts. The Journal of Membrane Biology, 213, 175-185. https://doi.org/10.1007/s00232-007-0027-8
|
[28]
|
Bentzen, B.H., Osadchii, O., Jespersen, T., et al. (2009) Activation of Big Conductance Ca2+-Activated K+ Channels (BK) Protects the Heart against Ischemia-Reperfusion Injury. Pflügers Archiv, 457, 979-988. https://doi.org/10.1007/s00424-008-0583-5
|
[29]
|
Cao, C.M., Xia, Q., Gao, Q., Chen, M. and Wong, T.M. (2005) Calcium-Activated Potassium Channel Triggers Cardioprotection of Ischemic Preconditioning. Journal of Pharmacology and Experimental Therapeutics, 312, 644-650. https://doi.org/10.1124/jpet.104.074476
|
[30]
|
Ohya, S., Kuwata, Y., Sakamoto, K., Muraki, K. and Imaizumi, Y. (2005) Cardioprotective Effects of Estradiol Include the Activation of Large-Conductance Ca2+-Activated K+ Channels in Cardiac Mitochondria. American Journal of Physiology-Heart and Circulatory Physiology, 289, H1635-H1642. https://doi.org/10.1152/ajpheart.00016.2005
|
[31]
|
Sato, T., Saito, T., Saegusa, N. and Nakaya, H. (2005) Mitochondrial Ca2+-Activated K+ Channels in Cardiac Myocytes: A Mechanism of the Cardioprotective Effect and Modulation by Protein Kinase A. Circulation, 111, 198-203. https://doi.org/10.1161/01.CIR.0000151099.15706.B1
|
[32]
|
Wang, X., Fisher, P.W., Xi, L. and Kukreja, R.C. (2008) Essential Role of Mitochondrial Ca2+-Activated and ATP-Sensitive K+ Channels in Sildenafil-Induced Late Cardioprotection. Journal of Molecular and Cellular Cardiology, 44, 105-113. https://doi.org/10.1016/j.yjmcc.2007.10.006
|
[33]
|
Xu, W., Liu, Y., Wang, S., et al. (2002) Cytoprotective Role of Ca2+-Activated K+ Channels in the Cardiac Inner Mitochondrial Membrane. Science, 298, 1029-1033. https://doi.org/10.1126/science.1074360
|
[34]
|
Borchert, G.H., Yang, C. and Kolar, F. (2011) Mitochondrial BKCa Channels Contribute to Protection of Cardiomyocytes Isolated from Chronically Hypoxic Rats. American Journal of Physiology-Heart and Circulatory Physiology, 300, H507-H513. https://doi.org/10.1152/ajpheart.00594.2010
|
[35]
|
Soltysinska, E., Bentzen, B.H., Barthmes, M., et al. (2014) KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury. PLoS ONE, 9, e103402. https://doi.org/10.1371/journal.pone.0103402
|
[36]
|
Kumar, P. and Prabhakar, N.R. (2012) Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body. Comprehensive Physiology, 2, 141-219. https://doi.org/10.1002/cphy.c100069
|
[37]
|
Otsubo, T., Kostuk, E.W., Balbir, A., Fujii, K. and Shirahata, M. (2011) Differential Expression of Large-Conductance Ca2+-Activated K Channels in the Carotid Body between DBA/2J and A/J Strains of Mice. Frontiers in Cellular Neuroscience, 5, 19. https://doi.org/10.3389/fncel.2011.00019
|
[38]
|
Thomas, D.A., Swaminathan, S., Beardsmore, C.S., et al. (1993) Comparison of Peripheral Chemoreceptor Responses in Monozygotic and Dizygotic Twin Infants. American Review of Respiratory Disease, 148, 1605-1609. https://doi.org/10.1164/ajrccm/148.6_Pt_1.1605
|
[39]
|
Prabhakar, N.R., Peng, Y.J. and Nanduri, J. (2018) Recent Advances in Understanding the Physiology of Hypoxic Sensing by the Carotid Body. F1000Research, 7, F1000 Faculty Rev-1900. https://doi.org/10.12688/f1000research.16247.1
|
[40]
|
Kim, H.H. and Choi, S. (2018) Therapeutic Aspects of Carbon Monoxide in Cardiovascular Disease. International Journal of Molecular Sciences, 19, 2381. https://doi.org/10.3390/ijms19082381
|
[41]
|
Wang, J. and Kim, D. (2018) Activation of Voltage-Dependent K+ Channels Strongly Limits Hypoxia-Induced Elevation of [Ca2+]i in Rat Carotid Body Glomus Cells. The Journal of Physiology, 596, 3119-3136. https://doi.org/10.1113/JP275275
|
[42]
|
Iturriaga, R. (2018) Translating Carotid Body Function into Clinical Medicine. The Journal of Physiology, 596, 3067-3077. https://doi.org/10.1113/JP275335
|
[43]
|
Lindsey, B.G., Nuding, S.C., Segers, L.S. and Morris, K.F. (2018) Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia. Physiology (Bethesda), 33, 281-297. https://doi.org/10.1152/physiol.00014.2018
|
[44]
|
Kis, A., Krick, S., Baumlin, N. and Salathe, M. (2016) Airway Hydration, Apical K+ Secretion, and the Large-Conductance, Ca2+-Activated and Voltage-Dependent Potassium (BK) Channel. Annals of the American Thoracic Society, 13, S163-S168.
|
[45]
|
Peppin, J.F., Raffa, R.B. and Schatman, M.E. (2020) The Polysubstance Overdose-Death Crisis. Journal of Pain Research, 13, 3405-3408. https://doi.org/10.2147/JPR.S295715
|
[46]
|
Couch, G., White, M. and de Gray, L. (2020) Central Nervous System Stimulants: Basic Pharmacology and Relevance to Anaesthesia and Critical Care. Anaesthesia & Intensive Care Medicine, 21, 503-511. https://doi.org/10.1016/j.mpaic.2020.07.005
|
[47]
|
McCartney, C.E., McClafferty, H., Huibant, J.-M., et al. (2005) A Cysteine-Rich Motif Confers Hypoxia Sensitivity to Mammalian Large Conductance Voltage- and Ca-Activated K (BK) Channel Alpha-Subunits. Proceedings of the National Academy of Sciences of the United States of America, 102, 17870-17876. https://doi.org/10.1073/pnas.0505270102
|
[48]
|
McLeod, J.F., Leempoels, J.M., Peng, S.X., et al. (2014) GAL-021, a New Intravenous BKCa-Channel Blocker, Is Well Tolerated and Stimulates Ventilation in Healthy Volunteers. British Journal of Anaesthesia, 113, 875-883. https://doi.org/10.1093/bja/aeu182
|
[49]
|
Cohen, M.V., Yang, X. and Downey, J.M. (2010) A2b Adenosine Receptors Can Change Their Spots. British Journal of Pharmacology, 159, 1595-1597. https://doi.org/10.1111/j.1476-5381.2010.00668.x
|
[50]
|
Qian, L., Liu, X. and Wang, R. (2014) Role of BKCa Channels in Diabetic Vascular Complications. Chinese Medical Journal, 127, 1775-1781.
|
[51]
|
Parajuli, S.P., Zheng, Y.M., Levin, R. and Wang, Y.X. (2016) Big-Conductance Ca2+-Activated K+ Channels in Physiological and Pathophysiological Urinary Bladder Smooth Muscle cells. Channels (Austin), 10, 355-364. https://doi.org/10.1080/19336950.2016.1180488
|
[52]
|
Harms, N.V. and Toris, C.B. (2013) Current Status of Unoprostone for the Management of Glaucoma and the Future of Its Use in the Treatment of Retinal Disease. Expert Opinion on Pharmacotherapy, 14, 105-113. https://doi.org/10.1517/14656566.2013.748038
|
[53]
|
Colwell, C.S. (2006) BK Channels and Circadian Output. Nature Neuroscience, 9, 985-986. https://doi.org/10.1038/nn0806-985
|
[54]
|
Zaman, T., De Oliveira, C., Smoka, M., et al. (2017) BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats. Journal of Neuroscience, 37, 4540-4551. https://doi.org/10.1523/JNEUROSCI.3699-16.2017
|