An Aminopyrrolidinyl Phosphonates—A New Class of Antibiotics: Facile Synthesis and Predicted Biological Activity

DOI: 10.4236/ijoc.2020.104013   PDF   HTML   XML   50 Downloads   155 Views  


A novel class of aminopyrrolidinyl phosphonates was synthesized in 74% - 80% isolated yield by the addition of three-fold excess of primary amines to diethyl 4-chloro-1-butynylphosphonates. The reaction was carried out at room temperature and in the absence of solvent or catalyst to give solely compounds which showed predicted biological activity based on PASS program. Some of the synthesized derivatives of antibiotics exhibit properties for the treatment of stroke, the treatment of acute neurological disorders, and can also be acetyl esterase inhibitors.

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Al Quntar, A. , Dweik, H. , Jabareen, A. , Gloriozova, T. and Dembitsky, V. (2020) An Aminopyrrolidinyl Phosphonates—A New Class of Antibiotics: Facile Synthesis and Predicted Biological Activity. International Journal of Organic Chemistry, 10, 170-181. doi: 10.4236/ijoc.2020.104013.

Conflicts of Interest

The authors declare no conflicts of interest regarding the publication of this paper.


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