[1]
|
Rodriguez-Caruncho, C. and Marsol, I.B. (2014) Antimalarials in Dermatology: Mechanism of Action, Indications, and Side Effects. Actas Dermo-Sifiliográficas (English Edition), 105, 243-252. https://doi.org/10.1016/j.adengl.2012.10.021
|
[2]
|
Al-Bari, M.A. (2015) Chloroquine Analogues in Drug Discovery: New Directions of Uses, Mechanisms of Actions and Toxic Manifestations from Malaria to Multifarious Diseases. Journal of Antimicrobial Chemotherapy, 70, 1608-1621. https://doi.org/10.1093/jac/dkv018
|
[3]
|
Mushtaque, M. and Shahjahan (2015) Reemergence of Chloroquine (CQ) Analogs as Multi-Targeting Antimalarial Agents: A Review. European Journal of Medicinal Chemistry, 90, 280-295. https://doi.org/10.1016/j.ejmech.2014.11.022
|
[4]
|
Rubin, M., Bernstein, H.N. and Zvaifler, N.J. (1963) Studies on the Pharmacology of Chloroquine: Recommendations for the Treatment of Chloroquine Retinopathy. Archives of Ophthalmology, 70, 474-481. https://doi.org/10.1001/archopht.1963.00960050476009
|
[5]
|
Lesiak, A., Narbutt, J., Kobos, J., Kordek, R., Sysa-Jedrzejowska, A., Norval, M. and Wozniacka, A. (2009) Systematic Administration of Chloroquine in Discoid Lupus Erythematosus Reduces Skin Lesions via Inhibition of Angiogenesis. Clinical and Experimental Dermatology: Clinical Dermatology, 34, 570-575. https://doi.org/10.1111/j.1365-2230.2008.03006.x
|
[6]
|
Dorner, T. (2010) Hydroxychloroquine in SLE: Old Drug, New Perspectives. Nature Reviews Rheumatology, 6, 10-11. https://doi.org/10.1038/nrrheum.2009.235
|
[7]
|
Joshi, P., Chakraborti, S., Ramirez-Vick, J.E., Ansari, Z.A., Shanker, V., Chakrabarti, P. and Singh, S.P. (2012) The Anticancer Activity of Chloroquine-Gold Nanoparticles against MCF-7 Breast Cancer Cells. Colloids and Surfaces B: Biointerfaces, 95, 195-200. https://doi.org/10.1016/j.colsurfb.2012.02.039
|
[8]
|
Abdel-Aziz, A.K., Shouman, S., El-Demerdash, E., Elgendy, M. and Abdel-Naim, A.B. (2014) Chloroquine Synergizes Sunitinib Cytotoxicity via Modulating Autophagic, Apoptotic and Angiogenic Machineries. Chemico-Biological Interactions, 217, 28-40. https://doi.org/10.1016/j.cbi.2014.04.007
|
[9]
|
Warhurst, D.C., Steele, J.C., Adagu, I.S., Craig, J.C. and Cullander, C. (2003) Hydroxychloroquine Is Much Less Active than Chloroquine against Chloroquine-Resistant Plasmodium falciparum, in Agreement with Its Physicochemical Properties. Journal of Antimicrobial Chemotherapy, 52, 188-193. https://doi.org/10.1093/jac/dkg319
|
[10]
|
Park, J., Choi, K., Jeong, E., Kwon, D., Benveniste, E.N. and Choi, C. (2004) Reactive Oxygen Species Mediate Chloroquine-Induced Expression of Chemokines by Human Astroglial Cells. Glia, 47, 9-20. https://doi.org/10.1002/glia.20017
|
[11]
|
Thomé, R., Lopes, S.C., Costa, F.T. and Verinaud, L. (2013) Chloroquine: Modes of Action of an Undervalued Drug. Immunology Letters, 153, 50-57. https://doi.org/10.1016/j.imlet.2013.07.004
|
[12]
|
Verbaanderd, C., Maes, H., Schaaf, M.B., Sukhatme, V.P., Pantziarka, P., Sukhatme, V., Agostinis, P. and Bouche, G. (2017) Repurposing Drugs in Oncology (ReDO)—Chloroquine and Hydroxychloroquine as Anti-Cancer Agents. eCancer Medical Science, 11. https://doi.org/10.3332/ecancer.2017.781
|
[13]
|
Costedoat-Chalumeau, N., Hulot, J.S., Amoura, Z., Delcourt, A., Maisonobe, T., Dorent, R., Bonnet, N., Sablé, R., Lechat, P., Wechsler, B. and Piette, J.C. (2007) Cardiomyopathy Related to Antimalarial Therapy with Illustrative Case Report. Cardiology, 107, 73-80. https://doi.org/10.1159/000094079
|
[14]
|
McChesney, E.W. (1983) Animal Toxicity and Pharmacokinetics of Hydroxychloroquine Sulfate. The American Journal of Medicine, 75, 11-18. https://doi.org/10.1016/0002-9343(83)91265-2
|
[15]
|
Liu, J., Cao, R., Xu, M., Wang, X., Zhang, H., Hu, H., Li, Y., Hu, Z., Zhong, W. and Wang, M. (2020) Hydroxychloroquine, a Less Toxic Derivative of Chloroquine, Is Effective in Inhibiting SARS-CoV-2 Infection in Vitro. Cell Discovery, 6, Article No. 16. https://doi.org/10.1038/s41421-020-0156-0
|
[16]
|
Ngabire, D. and Kim, G.D. (2017) Autophagy and Inflammatory Response in the Tumor Microenvironment. International Journal of Molecular Sciences, 18, 2016. https://doi.org/10.3390/ijms18092016
|
[17]
|
White, E. (2015) The Role for Autophagy in Cancer. The Journal of Clinical Investigation, 125, 42-46. https://doi.org/10.1172/JCI73941
|
[18]
|
Cuervo, A.M. and Wong, E. (2014) Chaperone-Mediated Autophagy: Roles in Disease and Aging. Cell Research, 24, 92-104. https://doi.org/10.1038/cr.2013.153
|
[19]
|
Waite, K.A., De-La Mota-Peynado, A., Vontz, G. and Roelofs, J. (2016) Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles. Journal of Biological Chemistry, 291, 3239-3253. https://doi.org/10.1074/jbc.M115.699124
|
[20]
|
Frake, R.A., Ricketts, T., Menzies, F.M. and Rubinsztein, D.C. (2015) Autophagy and Neurodegeneration. The Journal of Clinical Investigation, 125, 65-74. https://doi.org/10.1172/JCI73944
|
[21]
|
Deretic, V., Kimura, T., Timmins, G., Moseley, P., Chauhan, S. and Mandell, M. (2015) Immunologic Manifestations of Autophagy. The Journal of Clinical Investigation, 125, 75-84. https://doi.org/10.1172/JCI73945
|
[22]
|
Wang, R.C., Wei, Y., An, Z., Zou, Z., Xiao, G., Bhagat, G., White, M., Reichelt, J. and Levine, B. (2012) Akt-Mediated Regulation of Autophagy and Tumorigenesis through Beclin 1 Phosphorylation. Science, 338, 956-959. https://doi.org/10.1126/science.1225967
|
[23]
|
Cicchini, M., Chakrabarti, R., Kongara, S., Price, S., Nahar, R., Lozy, F., Zhong, H., Vazquez, A., Kang, Y. and Karantza, V. (2014) Autophagy Regulator BECN1 Suppresses Mammary Tumorigenesis Driven by WNT1 Activation and Following Parity. Autophagy, 10, 2036-2052. https://doi.org/10.4161/auto.34398
|
[24]
|
Lim, K.H. and Staudt, L.M. (2013) Toll-Like Receptor Signaling. Cold Spring Harbor Perspectives in Biology, 5, a011247. https://doi.org/10.1101/cshperspect.a011247
|
[25]
|
Salminen, A., Kaarniranta, K. and Kauppinen, A. (2013) Beclin 1 Interactome Controls the Crosstalk between Apoptosis, Autophagy and Inflammasome Activation: Impact on the Aging Process. Ageing Research Reviews, 12, 520-534. https://doi.org/10.1016/j.arr.2012.11.004
|
[26]
|
White, E. (2012) Deconvoluting the Context-Dependent Role for Autophagy in Cancer. Nature Reviews Cancer, 12, 401-410. https://doi.org/10.1038/nrc3262
|
[27]
|
Galluzzi, L., Kepp, O., Vander Heiden, M.G. and Kroemer, G. (2013) Metabolic Targets for Cancer Therapy. Nature Reviews Drug Discovery, 12, 829-846. https://doi.org/10.1038/nrd4145
|
[28]
|
Mathew, R., Kongara, S., Beaudoin, B., Karp, C.M., Bray, K., Degenhardt, K., Chen, G., Jin, S. and White, E. (2007) Autophagy Suppresses Tumor Progression by Limiting Chromosomal Instability. Genes & Development, 21, 1367-1381. https://doi.org/10.1101/gad.1545107
|
[29]
|
Xie, R., Wang, F., McKeehan, W.L. and Liu, L. (2011) Autophagy Enhanced by Microtubule-and Mitochondrion-Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis. Cancer Research, 71, 7537-7546. https://doi.org/10.1158/0008-5472.CAN-11-2170
|
[30]
|
Rello-Varona, S., Lissa, D., Shen, S., Niso-Santano, M., Senovilla, L., Marino, G., Vitale, I., Jemaá, M., Harper, F., Pierron, G. and Castedo, M. (2012) Autophagic Removal of Micronuclei. Cell Cycle, 11, 170-176. https://doi.org/10.4161/cc.11.1.18564
|
[31]
|
Liu, H., He, Z., von Rütte, T., Yousefi, S., Hunger, R.E. and Simon, H.U. (2013) Down-Regulation of Autophagy-Related Protein 5 (ATG5) Contributes to the Pathogenesis of Early-Stage Cutaneous Melanoma. Science Translational Medicine, 5, 202ra123. https://doi.org/10.1126/scitranslmed.3005864
|
[32]
|
Karantza-Wadsworth, V., Patel, S., Kravchuk, O., Chen, G., Mathew, R., Jin, S. and White, E. (2007) Autophagy Mitigates Metabolic Stress and Genome Damage in Mammary Tumorigenesis. Genes & Development, 21, 1621-1635. https://doi.org/10.1101/gad.1565707
|
[33]
|
Yang, S., Wang, X., Contino, G., Liesa, M., Sahin, E., Ying, H., Bause, A., Li, Y., Stommel, J.M., Dell’Antonio, G. and Mautner, J. (2011) Pancreatic Cancers Require Autophagy for Tumor Growth. Genes & Development, 25, 717-729. https://doi.org/10.1101/gad.2016111
|
[34]
|
Jain, A., Lamark, T., Sjottem, E., Larsen, K.B., Awuh, J.A., Overvatn, A., McMahon, M., Hayes, J.D. and Johansen, T. (2010) p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-Driven Gene Transcription. Journal of Biological Chemistry, 285, 22576-22591. https://doi.org/10.1074/jbc.M110.118976
|
[35]
|
Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Ando, J., Iwadate, M., Yamamoto, M. and Lee, M.S. (2011) Persistent Activation of Nrf2 through p62 in Hepatocellular Carcinoma Cells. Journal of Cell Biology, 193, 275-284. https://doi.org/10.1083/jcb.201102031
|
[36]
|
Vacchelli, E., Aranda, F., Eggermont, A., Galon, J., Sautès-Fridman, C., Cremer, I., Zitvogel, L., Kroemer, G. and Galluzzi, L. (2014) Trial Watch: Chemotherapy with Immunogenic Cell Death Inducers. Oncoimmunology, 3, e27878. https://doi.org/10.4161/onci.27878
|
[37]
|
Vacchelli, E., Senovilla, L., Eggermont, A., Fridman, W.H., Galon, J., Zitvogel, L., Kroemer, G. and Galluzzi, L. (2013) Trial Watch: Chemotherapy with Immunogenic Cell Death Inducers. Oncoimmunology, 2, e23510. https://doi.org/10.4161/onci.23510
|
[38]
|
Kroemer, G., Galluzzi, L., Kepp, O. and Zitvogel, L. (2013) Immunogenic Cell Death in Cancer Therapy. Annual Review of Immunology, 31, 51-72. https://doi.org/10.1146/annurev-immunol-032712-100008
|
[39]
|
Michaud, M., Martins, I., Sukkurwala, A.Q., Adjemian, S., Ma, Y., Pellegatti, P., Shen, S., Kepp, O., Scoazec, M., Mignot, G. and Rello-Varona, S. (2011) Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice. Science, 334, 1573-1577. https://doi.org/10.1126/science.1208347
|
[40]
|
Manic, G., Obrist, F., Kroemer, G., Vitale, I. and Galluzzi, L. (2014) Chloroquine and Hydroxychloroquine for Cancer Therapy. Molecular & Cellular Oncology, 1, e29911. https://doi.org/10.4161/mco.29911
|
[41]
|
Michaud, M., Xie, X., Bravo-San Pedro, J.M., Zitvogel, L., White, E. and Kroemer, G. (2014) An Autophagy-Dependent Anticancer Immune Response Determines the Efficacy of Melanoma Chemotherapy. Oncoimmunology, 3, e944047. https://doi.org/10.4161/21624011.2014.944047
|
[42]
|
Fu, L.L., Cheng, Y. and Liu, B. (2013) Beclin-1: Autophagic Regulator and Therapeutic Target in Cancer. The International Journal of Biochemistry & Cell Biology, 45, 921-924. https://doi.org/10.1016/j.biocel.2013.02.007
|
[43]
|
Chen, N. and Karantza, V. (2011) Autophagy as a Therapeutic Target in Cancer. Cancer Biology & Therapy, 11, 157-168. https://doi.org/10.4161/cbt.11.2.14622
|
[44]
|
Lee, S.J., Silverman, E. and Bargman, J.M. (2011) The Role of Antimalarial Agents in the Treatment of SLE and Lupus Nephritis. Nature Reviews Nephrology, 7, 718. https://doi.org/10.1038/nrneph.2011.150
|
[45]
|
Maes, H., Rubio, N., Garg, A.D. and Agostinis, P. (2013) Autophagy: Shaping the Tumor Microenvironment and Therapeutic Response. Trends in Molecular Medicine, 19, 428-446. https://doi.org/10.1016/j.molmed.2013.04.005
|
[46]
|
Carmeliet, P. and Jain, R.K. (2011) Principles and Mechanisms of Vessel Normalization for Cancer and Other Angiogenic Diseases. Nature Reviews Drug Discovery, 10, 417-427. https://doi.org/10.1038/nrd3455
|
[47]
|
Pantziarka, P., Bouche, G., Meheus, L., Sukhatme, V. and Sukhatme, V.P. (2014) Repurposing Drugs in Oncology (ReDO)—Mebendazole as an Anti-Cancer Agent. eCancer Medical Science, 8. https://doi.org/10.3332/ecancer.2014.485
|
[48]
|
Dobrowolski, R. and De Robertis, E.M. (2012) Endocytic Control of Growth Factor Signalling: Multivesicular Bodies as Signalling Organelles. Nature Reviews Molecular Cell Biology, 13, 53-60. https://doi.org/10.1038/nrm3244
|
[49]
|
Inaba, M. and Maruyama, E. (1988) Reversal of Resistance to Vincristine in P388 Leukemia by Various Polycyclic Clinical Drugs, with a Special Emphasis on Quinacrine. Cancer Research, 48, 2064-2067.
|
[50]
|
Mirzoeva, O.K., Hann, B., Hom, Y.K., Debnath, J., Aftab, D., Shokat, K. and Korn, W.M. (2011) Autophagy Suppression Promotes Apoptotic Cell Death in Response to Inhibition of the PI3K-mTOR Pathway in Pancreatic Adenocarcinoma. Journal of Molecular Medicine, 89, 877-889. https://doi.org/10.1007/s00109-011-0774-y
|
[51]
|
Li, H., Jin, X., Zhang, Z., Xing, Y. and Kong, X. (2013) Inhibition of Autophagy Enhances Apoptosis Induced by the PI3K/AKT/mTor Inhibitor NVP-BEZ235 in Renal Cell Carcinoma Cells. Cell Biochemistry and Function, 31, 427-433. https://doi.org/10.1002/cbf.2917
|
[52]
|
Zhang, Y., Cheng, Y., Ren, X., Zhang, L., Yap, K.L., Wu, H., Patel, R., Liu, D., Qin, Z.H., Shih, I.M. and Yang, J.M. (2012) NAC1 Modulates Sensitivity of Ovarian Cancer Cells to Cisplatin by Altering the HMGB1-Mediated Autophagic Response. Oncogene, 31, 1055-1064. https://doi.org/10.1038/onc.2011.290
|
[53]
|
Kim, E.L., Wüstenberg, R., Rübsam, A., Schmitz-Salue, C., Warnecke, G., Bücker, E.M., Pettkus, N., Speidel, D., Rohde, V., Schulz-Schaeffer, W. and Deppert, W. (2010) Chloroquine Activates the p53 Pathway and Induces Apoptosis in Human Glioma Cells. Neuro-Oncology, 12, 389-400. https://doi.org/10.1093/neuonc/nop046
|
[54]
|
Loehberg, C.R., Thompson, T., Kastan, M.B., Maclean, K.H., Edwards, D.G., Kittrell, F.S., Medina, D., Conneely, O.M. and O’Malley, B.W. (2007) Ataxia Telangiectasia-Mutated and p53 Are Potential Mediators of Chloroquine-Induced Resistance to Mammary Carcinogenesis. Cancer Research, 67, 12026-12033. https://doi.org/10.1158/0008-5472.CAN-07-3058
|
[55]
|
Zaidi, A.U., McDonough, J.S., Klocke, B.J., Latham, C.B., Korsmeyer, S.J., Flavell, R.A., Schmidt, R.E. and Roth, K.A. (2001) Chloroquine-Induced Neuronal Cell Death Is p53 and Bcl-2 Family-Dependent but Caspase-Independent. Journal of Neuropathology & Experimental Neurology, 60, 937-945. https://doi.org/10.1093/jnen/60.10.937
|
[56]
|
Mohamed, M.M. (2005) Anti-Malarial Chloroquine Stimulate p53-Apoptotic Pathway in Rat Hepatocytes. Journal of the Egyptian Society of Parasitology, 35, 19-32.
|
[57]
|
Loehberg, C.R., Strissel, P.L., Dittrich, R., Strick, R., Dittmer, J., Dittmer, A., Fabry, B., Kalender, W.A., Koch, T., Wachter, D.L. and Groh, N. (2012) Akt and p53 Are Potential Mediators of Reduced Mammary Tumor Growth by Chloroquine and the mTOR Inhibitor RAD001. Biochemical Pharmacology, 83, 480-488. https://doi.org/10.1016/j.bcp.2011.11.022
|
[58]
|
Balic, A., Sorensen, M.D., Trabulo, S.M., Sainz, B., Cioffi, M., Vieira, C.R., Miranda-Lorenzo, I., Hidalgo, M., Kleeff, J., Erkan, M. and Heeschen, C. (2014) Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling. Molecular Cancer Therapeutics, 13, 1758-1771. https://doi.org/10.1158/1535-7163.MCT-13-0948
|
[59]
|
Maycotte, P., Aryal, S., Cummings, C.T., Thorburn, J., Morgan, M.J. and Thorburn, A. (2012) Chloroquine Sensitizes Breast Cancer Cells to Chemotherapy Independent of Autophagy. Autophagy, 8, 200-212. https://doi.org/10.4161/auto.8.2.18554
|
[60]
|
Bakkenist, C.J. and Kastan, M.B. (2003) DNA Damage Activates ATM through Intermolecular Autophosphorylation and Dimer Dissociation. Nature, 421, 499-506. https://doi.org/10.1038/nature01368
|
[61]
|
Wenzel, N.I., Chavain, N., Wang, Y., Friebolin, W., Maes, L., Pradines, B., Lanzer, M., Yardley, V., Brun, R., Herold-Mende, C. and Biot, C. (2010) Antimalarial versus Cytotoxic Properties of Dual Drugs Derived from 4-Aminoquinolines and Mannich Bases: Interaction with DNA. Journal of Medicinal Chemistry, 53, 3214-3226. https://doi.org/10.1021/jm9018383
|
[62]
|
Solomon, V.R. and Lee, H. (2009) Chloroquine and Its Analogs: A New Promise of an Old Drug for Effective and Safe Cancer Therapies. European Journal of Pharmacology, 625, 220-233. https://doi.org/10.1016/j.ejphar.2009.06.063
|
[63]
|
Cuomo, F., Altucci, L. and Cobellis, G. (2019) Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy. Cancers, 11, 1465. https://doi.org/10.3390/cancers11101465
|
[64]
|
Esdaile, J.M., Koehler, B.E., Suarez-Almazor, M., Easterbrook, M., Jamali, F., Petty, R.E., Koehn, C., Koren, G., Sauder, D., MacDougall, B. and Rosenberg, E. (2000) Canadian Consensus Conference on Hydroxychloroquine. Journal of Rheumatology, 27, 2919-2921.
|
[65]
|
Gladman, D.D. (1998) Aspects of Use of Antimalarials in Systemic Lupus Erythematosus. Journal of Rheumatology, 25, 983-985.
|
[66]
|
Scofield, R.H. and Oates, J.C. (2009) The Place of William Osler in the Description of Systemic Lupus Erythematosus. The American Journal of the Medical Sciences, 338, 409-412.
|
[67]
|
Momose, Y., Arai, S., Eto, H., Kishimoto, M. and Okada, M. (2013) Experience with the Use of Hydroxychloroquine for the Treatment of Lupus Erythematosus. The Journal of Dermatology, 40, 94-97. https://doi.org/10.1111/1346-8138.12005
|
[68]
|
Potvin, F., Petitclerc, E., Marceau, F. and Poubelle, P.E. (1997) Mechanisms of Action of Antimalarials in Inflammation: Induction of Apoptosis in Human Endothelial Cells. The Journal of Immunology, 158, 1872-1879.
|
[69]
|
Kuhn, A., Ruland, V. and Bonsmann, G. (2011) Cutaneous lupus Erythematosus: Update of Therapeutic Options: Part II. Journal of the American Academy of Dermatology, 65, e195-e213. https://doi.org/10.1016/j.jaad.2010.06.017
|
[70]
|
Prete, M., Racanelli, V., Digiglio, L., Vacca, A., Dammacco, F. and Perosa, F. (2011) Extra-Articular Manifestations of Rheumatoid Arthritis: An Update. Autoimmunity Reviews, 11, 123-131. https://doi.org/10.1016/j.autrev.2011.09.001
|
[71]
|
Cimmino, M.A., Parisi, M., Moggiana, G., Mela, G.S. and Accardo, S. (1998) Prevalence of Rheumatoid Arthritis in Italy: The Chiavari Study. Annals of the Rheumatic Diseases, 57, 315-318. https://doi.org/10.1136/ard.57.5.315
|
[72]
|
Carbonell, J., Cobo, T., Balsa, A., Descalzo, M.A. and Carmona, L., for SERAP Study Group (2008) The Incidence of Rheumatoid Arthritis in Spain: Results from a Nationwide Primary Care Registry. Rheumatology, 47, 1088-1092. https://doi.org/10.1093/rheumatology/ken205
|
[73]
|
Plenge, R.M. (2009) Rheumatoid Arthritis Genetics: 2009 Update. Current Rheumatology Reports, 11, 351-356.
|
[74]
|
Smolen, J.S. and Steiner, G. (2003) Therapeutic Strategies for Rheumatoid Arthritis. Nature Reviews Drug Discovery, 2, 473-488.
|
[75]
|
O’Dell, J.R. (2004) Therapeutic Strategies for Rheumatoid Arthritis. New England Journal of Medicine, 350, 2591-2602. https://doi.org/10.1056/NEJMra040226
|
[76]
|
Smolen, J.S., Aletaha, D., Koeller, M., Weisman, M.H. and Emery, P. (2007) New Therapies for Treatment of Rheumatoid Arthritis. The Lancet, 370, 1861-1874. https://doi.org/10.1016/S0140-6736(07)60784-3
|
[77]
|
Miao, C.G., Yang, Y.Y., He, X., Li, X.F., Huang, C., Huang, Y., Zhang, L., Lv, X.W., Jin, Y. and Li, J. (2013) Wnt Signaling Pathway in Rheumatoid Arthritis, with Special Emphasis on the Different Roles in Synovial Inflammation and Bone Remodeling. Cellular Signalling, 25, 2069-2078. https://doi.org/10.1016/j.cellsig.2013.04.002
|
[78]
|
Rainsford, K.D., Parke, A.L., Clifford-Rashotte, M. and Kean, W.F. (2015) Therapy and Pharmacological Properties of Hydroxychloroquine and Chloroquine in Treatment of Systemic Lupus Erythematosus, Rheumatoid Arthritis and Related Diseases. Inflammopharmacology, 23, 231-269. https://doi.org/10.1007/s10787-015-0239-y
|
[79]
|
Circu, M., Cardelli, J., Barr, M., O’Byrne, K., Mills, G. and El-Osta, H. (2017) Modulating Lysosomal Function through Lysosome Membrane Permeabilization or Autophagy Suppression Restores Sensitivity to Cisplatin in Refractory Non-Small-Cell Lung Cancer Cells. PLoS ONE, 12, e0184922. https://doi.org/10.1371/journal.pone.0184922
|
[80]
|
Mauthe, M., Orhon, I., Rocchi, C., Zhou, X., Luhr, M., Hijlkema, K.J., Coppes, R.P., Engedal, N., Mari, M. and Reggiori, F. (2018) Chloroquine Inhibits Autophagic Flux by Decreasing Autophagosome-Lysosome Fusion. Autophagy, 14, 1435-1455. https://doi.org/10.1080/15548627.2018.1474314
|
[81]
|
Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C.A., Zhang, X. and Chen, Z.J. (2014) The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-Like Conformational Changes in the Activation Loop. Cell Reports, 6, 421-430. https://doi.org/10.1016/j.celrep.2014.01.003
|
[82]
|
Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C. and Chen, Z.J. (2013) Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is an Endogenous High-Affinity Ligand for STING. Molecular Cell, 51, 226-235. https://doi.org/10.1016/j.molcel.2013.05.022
|
[83]
|
Shu, C., Li, X. and Li, P. (2014) The Mechanism of Double-Stranded DNA Sensing through the cGAS-STING Pathway. Cytokine & Growth Factor Reviews, 25, 641-648. https://doi.org/10.1016/j.cytogfr.2014.06.006
|
[84]
|
An, J., Woodward, J.J., Sasaki, T., Minie, M. and Elkon, K.B. (2015) Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase–DNA Interaction. The Journal of Immunology, 194, 4089-4093. https://doi.org/10.4049/jimmunol.1402793
|
[85]
|
Dijkmans, B.A. and Verweij, C.L. (1997) Chloroquine and Hydroxychloroquine Equally Affect Tumor Necrosis Factor-Alpha, Interleukin 6, and Interferon-Gamma Production by Peripheral Blood Mononuclear Cells. The Journal of Rheumatology, 24, 55-60.
|
[86]
|
Famaey, J.P., Fontaine, J. and Reuse, J. (1975) Inhibiting Effects of Morphine, Chloroquine, Nonsteroidal and Steroidal Anti-Inflammatory Drugs on Electrically-Induced Contractions of Guinea-Pig Ileum and the Reversing Effect of Prostaglandins. Agents and Actions, 5, 354-358. https://doi.org/10.1007/BF02205242
|
[87]
|
Ruzicka, T. and Printz, M.P. (1982) Arachidonic Acid Metabolism in Guinea Pig Skin: Effects of Chloroquine. Agents and Actions, 12, 527-529. https://doi.org/10.1007/BF01965938
|
[88]
|
Gibson, T., Emery, P., Armstrong, R.D., Crisp, A.J. and Panayi, G.S. (1987) Combined D-Penicillamine and Chloroquine Treatment of Rheumatoid Arthritis—A Comparative Study. Rheumatology, 26, 279-284. https://doi.org/10.1093/rheumatology/26.4.279
|
[89]
|
Rosamond, W. (2008) 2008 Update: A Report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation, 117, e25-146.
|
[90]
|
Lloyd-Jones, D.M., Wang, T.J., Leip, E.P., Larson, M.G., Levy, D., Vasan, R.S., D’Agostino, R.B., Massaro, J.M., Beiser, A., Wolf, P.A. and Benjamin, E.J. (2004) Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study. Circulation, 110, 1042. https://doi.org/10.1161/01.CIR.0000140263.20897.42
|
[91]
|
Fuster, V., Rydén, L.E., Cannom, D.S., Crijns, H.J., Curtis, A.B., Ellenbogen, K.A., Halperin, J.L., Le Heuzey, J.Y., Kay, G.N., Lowe, J.E. and Olsson, S.B. (2006) Acc/aha/esc 2006 Guidelines for the Management of Patients with Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation): Developed in Collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation, 114, e257-e354. https://doi.org/10.1093/eurheartj/ehm315
|
[92]
|
Atienza, F., Almendral, J., Moreno, J., Vaidyanathan, R., Talkachou, A., Kalifa, J., Arenal, A., Villacastin, J.P., Torrecilla, E.G., Sánchez, A. and Ploutz-Snyder, R. (2006) CLINICAL PERSPECTIVE. Circulation, 114, 2434-2442.
|
[93]
|
Mandapati, R., Skanes, A., Chen, J., Berenfeld, O. and Jalife, J. (2000) Stable Microreentrant Sources as a Mechanism of Atrial Fibrillation in the Isolated Sheep Heart. Circulation, 101, 194-199. https://doi.org/10.1161/01.CIR.101.2.194
|
[94]
|
Kalifa, J., Jalife, J., Zaitsev, A.V., Bagwe, S., Warren, M., Moreno, J., Berenfeld, O. and Nattel, S. (2003) Intra-Atrial Pressure Increases Rate and Organization of Waves Emanating from the Superior Pulmonary Veins during Atrial Fibrillation. Circulation, 108, 668-671. https://doi.org/10.1161/01.CIR.0000086979.39843.7B
|
[95]
|
Burrell Jr., Z.L. and Martinez, A.C. (1958) Chloroquine and Hydroxychloroquine in the Treatment of Cardiac Arrhythmias. The New England Journal of Medicine, 258, 798-800. https://doi.org/10.1056/NEJM195804172581608
|
[96]
|
Sanchez-Chapula, J.A., Salinas-Stefanon, E., Torres-Jacome, J., Benavides-Haro, D.E. and Navarro-Polanco, R.A. (2001) Blockade of Currents by the Antimalarial Drug Chloroquine in Feline Ventricular Myocytes. Journal of Pharmacology and Experimental Therapeutics, 297, 437-445.
|
[97]
|
Dharmashankar, K. and Widlansky, M.E. (2010) Vascular Endothelial Function and Hypertension: Insights and Directions. Current Hypertension Reports, 12, 448-455. https://doi.org/10.1007/s11906-010-0150-2
|
[98]
|
Okuda, T. and Grollman, A. (1967) Passive Transfer of Autoimmune Induced Hypertension in the Rat by Lymph Node Cells. Texas Reports on Biology and Medicine, 25, 257-264.
|
[99]
|
Mathis, K.W., Broome, H.J. and Ryan, M.J. (2014) Autoimmunity: An Underlying Factor in the Pathogenesis of Hypertension. Current Hypertension Reports, 16, Article No.: 424. https://doi.org/10.1007/s11906-014-0424-1
|
[100]
|
McCarthy, C.G., Goulopoulou, S., Wenceslau, C.F., Spitler, K., Matsumoto, T. and Webb, R.C. (2014) Toll-Like Receptors and Damage-Associated Molecular Patterns: Novel Links between Inflammation and Hypertension. American Journal of Physiology-Heart and Circulatory Physiology, 306, H184-H196. https://doi.org/10.1152/ajpheart.00328.2013
|
[101]
|
Chan, C.T., Sobey, C.G., Lieu, M., Ferens, D., Kett, M.M., Diep, H., et al. (2015) Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension. Hypertension, 66, 1023-1033. https://doi.org/10.1161/HYPERTENSIONAHA.115.05779
|
[102]
|
Aranow, C. and Ginzler, E.M. (2000) Epidemiology of Cardiovascular Disease in Systemic Lupus Erythematosus. Lupus, 9, 166-169. https://doi.org/10.1191/096120300678828208
|
[103]
|
Mellana, W.M., Aronow, W.S., Palaniswamy, C. and Khera, S. (2012) Rheumatoid Arthritis: Cardiovascular Manifestations, Pathogenesis, and Therapy. Current Pharmaceutical Design, 18, 1450-1456. https://doi.org/10.2174/138161212799504795
|
[104]
|
Scherbel, A.L., Schuchter, S.L. and Harrison, J.W. (1957) Comparison of Effects of Two Antimalarial Agents, Hydroxychloroquine Sulfate and Chloroquine Phosphate, in Patients with Rheumatoid Arthitis. Cleveland Clinic Journal of Medicine, 24, 98-104. https://doi.org/10.3949/ccjm.24.2.98
|
[105]
|
Tye, M.J., White, H., Appel, B. and Ansell, H.B. (1959) Lupus Erythematosus Treated with a Combination of Quinacrine, Hydroxychloroquine and Chloroquine. The New England Journal of Medicine, 260, 63-66. https://doi.org/10.1056/NEJM195901082600203
|
[106]
|
Croyle, L. and Morand, E.F. (2015) Optimizing the Use of Existing Therapies in Lupus. International Journal of Rheumatic Diseases, 18, 129-137. https://doi.org/10.1111/1756-185X.12551
|
[107]
|
McCarthy, C.G., Wenceslau, C.F., Goulopoulou, S., Ogbi, S., Matsumoto, T. and Webb, R.C. (2016) Autoimmune Therapeutic Chloroquine Lowers Blood Pressure and Improves Endothelial Function in Spontaneously Hypertensive Rats. Pharmacological Research, 113, 384-394. https://doi.org/10.1016/j.phrs.2016.09.008
|
[108]
|
McCarthy, C.G., Wenceslau, C.F., Goulopoulou, S., Baban, B., Matsumoto, T. and Webb, R.C. (2017) Chloroquine Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats. American Journal of Hypertension, 30, 173-181. https://doi.org/10.1093/ajh/hpw113
|
[109]
|
Gomez-Guzman, M., Jimenez, R., Romero, M., Sanchez, M., Zarzuelo, M.J., Gomez-Morales, M., et al. (2014) Chronic Hydroxychloroquine Improves Endothelial Dysfunction and Protects Kidney in a Mouse Model of Systemic Lupus Erythematosus. Hypertension, 64, 330-337. https://doi.org/10.1161/HYPERTENSIONAHA.114.03587
|
[110]
|
WHO (1999) Definition, Diagnosis, and Classification of Diabetes Mellitus and Its Complications—Report of a WHO Consultation. World Health Organization, Geneva.
|
[111]
|
Karimulla, S.K. and Kumar, B.P. (2011) Anti-Diabetic and Anti-Hyperlipidemic Activity of Bark of Bruguiera gymnorrhiza on Streptozotocin-Induced Diabetic Rats. Asian Journal of Pharmaceutical Science & Technology, 1, 4-7.
|
[112]
|
Rynes, R.I. (1997) Antimalarial Drugs in the Treatment of Rheumatological Diseases. Rheumatology, 36, 799-805. https://doi.org/10.1093/rheumatology/36.7.799
|
[113]
|
Mohammady, M, Amini, M.A. and Ghafghazi, T. (2002) Effect of Chloroquine on Diabetes Control in Type 2 Diabetic Patients. Iranian Journal of Endocrinology and Metabolism, 4, 213-216.
|
[114]
|
Rekedal, L.R., Massarotti, E., Garg, R., Bhatia, R., Gleeson, T., Lu, B. and Solomon, D.H. (2010) Changes in Glycosylated Hemoglobin after Initiation of Hydroxychloroquine or Methotrexate Treatment in Diabetes Patients with Rheumatic Diseases. Arthritis & Rheumatism, 62, 3569-3573. https://doi.org/10.1002/art.27703
|
[115]
|
Solomon, D.H., Garg, R., Lu, B., Todd, D.J., Mercer, E., Norton, T. and Massarotti, E. (2014) Effect of Hydroxychloroquine on Insulin Sensitivity and Lipid Parameters in Rheumatoid Arthritis Patients without Diabetes Mellitus: A Randomized, Blinded Crossover Trial. Arthritis Care & Research, 66, 1246-1251. https://doi.org/10.1002/acr.22285
|
[116]
|
Hage, M.P., Al-Badri, M.R. and Azar, S.T. (2014) A Favorable Effect of Hydroxychloroquine on Glucose and Lipid Metabolism beyond Its Anti-Inflammatory Role. Therapeutic Advances in Endocrinology and Metabolism, 5, 77-85.
|
[117]
|
Paul, H. (2018) Managing Uncontrolled Type 2 Diabetes: Role of Hydroxychloroquine in Therapy as AD on Antidiabetic Agent: A Case Study. EC Endocrinology and Metabolic Research, 3, 84-88.
|
[118]
|
Kobayashi, M., Iwasaki, M. and Shigeta, Y. (1980) Receptor Mediated Insulin Degradation Decreased by Chloroquine in Isolated Rat Adipocytes. The Journal of Biochemistry, 88, 39-44.
|
[119]
|
Smith, G.D., Amos, T.A.S., Mahler, R. and Peters, T.J. (1987) Effect of Chloroquine on Insulin and Glucose Homoeostasis in Normal Subjects and Patients with Non-Insulin-Dependent Diabetes Mellitus. British Medical Journal (Clinical Research Edition), 294, 465-467. https://doi.org/10.1136/bmj.294.6570.465
|
[120]
|
Powrie, J.K., Smith, G.D., Shojaee-Moradie, F., Sonksen, P.H. and Jones, R.H. (1991) Mode of Action of Chloroquine in Patients with Non-Insulin-Dependent Diabetes Mellitus. American Journal of Physiology-Endocrinology and Metabolism, 260, E897-E904. https://doi.org/10.1152/ajpendo.1991.260.6.E897
|
[121]
|
Blazar, B.R., Whitley, C.B., Kitabchi, A.E., Tsai, M.Y., Santiago, J., White, N., Stentz, F.B. and Brown, D.M. (1984) In Vivo Chloroquine-Induced Inhibition of Insulin Degradation in a Diabetic Patient with Severe Insulin Resistance. Diabetes, 33, 1133-1137.
|
[122]
|
Kumar, V., Singh, M.P., Singh, A.P., Pandey, M.S., Kumar, S. and Kumar, S. (2018) Efficacy and Safety of Hydroxychloroquine When Added to Stable Insulin Therapy in Combination with Metformin and Glimepiride in Patients with Type 2 Diabetes Compare to Sitagliptin. International Journal of Basic & Clinical Pharmacology, 7, 1959-1964. https://doi.org/10.18203/2319-2003.ijbcp20183930
|
[123]
|
Chakravorty, S., Purkait, I., Pareek, A. and Talware, A. (2017) Hydroxychloroquine: Looking into the Future. Romanian Journal of Diabetes Nutrition and Metabolic Diseases, 24, 369-375. https://doi.org/10.1515/rjdnmd-2017-0043
|
[124]
|
Emami, J., Pasutto, F.M., Mercer, J.R. and Jamali, F. (1998) Inhibition of Insulin Metabolism by Hydroxychloroquine and Its Enantiomers in Cytosolic Fraction of Liver Homogenates from Healthy and Diabetic Rats. Life Sciences, 64, 325-335. https://doi.org/10.1016/S0024-3205(98)00568-2
|
[125]
|
Mercer, E., Rekedal, L., Garg, R., Lu, B., Massarotti, E.M. and Solomon, D.H. (2012) Hydroxychloroquine Improves Insulin Sensitivity in Obese Non-Diabetic Individuals. Arthritis Research & Therapy, 14, Article No. R135. https://doi.org/10.1186/ar3868
|
[126]
|
Halaby, M.J., Kastein, B.K. and Yang, D.Q. (2013) Chloroquine Stimulates Glucose Uptake and Glycogen Synthase in Muscle Cells through Activation of Akt. Biochemical and Biophysical Research Communications, 435, 708-713. https://doi.org/10.1016/j.bbrc.2013.05.047
|
[127]
|
Petri, M., Spence, D.E., Bone, L.R. and Hochberg, M.C. (1992) Coronary Artery Disease Risk Factors in the Johns Hopkins Lupus Cohort: Prevalence, Recognition by Patients, and Preventive Practices. Medicine, 71, 291-302. https://doi.org/10.1097/00005792-199209000-00004
|
[128]
|
Leong, K.H., Koh, E.T., Feng, P.H. and Boey, M.L. (1994) Lipid Profiles in Patients with Systemic Lupus Erythematosus. The Journal of Rheumatology, 21, 1264-1267.
|
[129]
|
Wozniacka, A., Lesiak, A., Smigielski, J. and Sysa-Jedrzejowska, A. (2005) Chloroquine Influence on Lipid Metabolism and Selected Laboratory Parameters. Przeglad lekarski, 62, 855-859.
|
[130]
|
Beynen, A., Van Der Molen, A. and Geelen, M. (1981) Inhibition of Hepatic Cholesterol Biosynthesis by Chloroquine. Lipids, 16, 472-474. https://doi.org/10.1007/BF02535017
|
[131]
|
Sachet, J.C., Borba, E.F., Bonfa, E., Vinagre, C.G., Silva, V.M. and Maranhao, R.C. (2007) Chloroquine Increases Low-Density Lipoprotein Removal from Plasma in Systemic Lupus Patients. Lupus, 16, 273-278. https://doi.org/10.1177/09612033070160040901
|
[132]
|
Cairoli, E., Rebella, M., Danese, N., Garra, V. and Borba, E.F. (2012) Hydroxychloroquine Reduces Low-Density Lipoprotein Cholesterol Levels in Systemic Lupus Erythematosus: A Longitudinal Evaluation of the Lipid-Lowering Effect. Lupus, 21, 1178-1182. https://doi.org/10.1177/0961203312450084
|
[133]
|
McEntegart, A., Capell, H.A., Creran, D., Rumley, A., Woodward, M. and Lowe, G.D. (2001) Cardiovascular Risk Factors, Including Thrombotic Variables, in a Population with Rheumatoid Arthritis. Rheumatology, 40, 640-644. https://doi.org/10.1093/rheumatology/40.6.640
|
[134]
|
Shah, M.A., Shah, A.M. and Krishnan, E. (2009) Poor Outcomes after Acute Myocardial Infarction in Systemic Lupus Erythematosus. The Journal of Rheumatology, 36, 570-575. https://doi.org/10.3899/jrheum.080373
|
[135]
|
Rahman, P., Gladman, D.D., Urowitz, M.B., Yuen, K., Hallett, D. and Bruce, I.N. (1999) The Cholesterol Lowering Effect of Antimalarial Drugs Is Enhanced in Patients with Lupus Taking Corticosteroid Drugs. The Journal of Rheumatology, 26, 325.
|
[136]
|
King, M.A., Ganley, I.G. and Flemington, V. (2016) Inhibition of Cholesterol Metabolism Underlies Synergy between mTOR Pathway Inhibition and Chloroquine in Bladder Cancer Cells. Oncogene, 35, 4518-4528. https://doi.org/10.1038/onc.2015.511
|
[137]
|
Zhou, B., Xia, Y. and She, J. (2020) Dysregulated Serum Lipid Profile and Its Correlation to Disease Activity in Young Female Adults Diagnosed with Systemic Lupus Erythematosus: A Cross-Sectional Study. Lipids in Health and Disease, 19, Article No. 40. https://doi.org/10.1186/s12944-020-01232-8
|
[138]
|
Mercado, M.V., Munoz-Valle, J.F., Santos, A., Bernard-Medina, A.G., Martinez-Bonilla, G., Paczka, J.A., Ruiz-García, H., Orozco-Alcalá, J., Orozco-Barocio, G., Quezada-Arellano, D. and Gurrola-Díaz, C. (2002) Evaluation of Lipid Profile, Macular Toxicity and Clinical Manifestations According to APO E Genotype in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients Treated with Chloroquine. Scandinavian Journal of Rheumatology, 31, 32-37. https://doi.org/10.1080/030097402317255345
|
[139]
|
Hodis, H.N., Quismorio Jr., F.P., Wickham, E. and Blankenhorn, D.H. (1993) The Lipid, Lipoprotein, and Apolipoprotein Effects of Hydroxychloroquine in Patients with Systemic Lupus Erythematosus. The Journal of Rheumatology, 20, 661-665.
|
[140]
|
Beynen, A.C. (1986) Could Chloroquine Be of Value in the Treatment of Hypercholesterolemia? Artery, 13, 340-351.
|
[141]
|
Edwards, M.H., Pierangeli, S., Liu, X., Barker, J.H., Anderson, G. and Harris, E.N. (1997) Hydroxychloroquine Reverses Thrombogenic Properties of Antiphospholipid Antibodies in Mice. Circulation, 96, 4380-4384. https://doi.org/10.1161/01.CIR.96.12.4380
|
[142]
|
Lafyatis, R., York, M. and Marshak-Rothstein, A. (2006) Antimalarial Agents: Closing the Gate on Toll-Like Receptors? Arthritis & Rheumatism, 54, 3068-3070. https://doi.org/10.1002/art.22157
|
[143]
|
Emami, J., Gerstein, H.C., Pasutto, F.M., et al. (1999) Insulin-Sparing Effect of Hydroxychloroquine in Diabetic Rats Is Concentration Dependent. Canadian Journal of Physiology and Pharmacology, 77, 118-123. https://doi.org/10.1139/y98-146
|
[144]
|
Fox, R.I. (1993) Mechanism of Action of Hydroxychloroquine as an Antirheumatic Drug. Seminars in Arthritis and Rheumatism, 23, 82-91. https://doi.org/10.1016/S0049-0172(10)80012-5
|
[145]
|
Ben-Zvi, I., Kivity, S., Langevitz, P., et al. (2012) Hydroxychloroquine: From Malaria to Autoimmunity. Clinical Reviews in Allergy & Immunology, 42, 145-153. https://doi.org/10.1007/s12016-010-8243-x
|
[146]
|
Wellems, T.E. and Plowe, C.V. (2001) Chloroquine-Resistant Malaria. The Journal of Infectious Diseases, 184, 770-776. https://doi.org/10.1086/322858
|
[147]
|
Siswantoro, H., Russell, B., Ratcliff, A., Prasetyorini, B., Chalfein, F., Marfurt, J., Kenangalem, E., Wuwung, M., Piera, K.A., Ebsworth, E.P. and Anstey, N.M. (2011) In Vivo and in Vitro Efficacy of Chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. Antimicrobial Agents and Chemotherapy, 55, 197-202. https://doi.org/10.1128/AAC.01122-10
|
[148]
|
O’Neill, P.M., Bray, P.G., Hawley, S.R., Ward, S.A. and Park, B.K. (1998) 4-Aminoquinolines—Past, Present, and Future: A Chemical Perspective. Pharmacology & Therapeutics, 77, 29-58. https://doi.org/10.1016/S0163-7258(97)00084-3
|
[149]
|
Rolain, J.M., Colson, P. and Raoult, D. (2007) Recycling of Chloroquine and Its Hydroxyl Analogue to Face Bacterial, Fungal and Viral Infections in the 21st Century. International Journal of Antimicrobial Agents, 30, 297-308. https://doi.org/10.1016/j.ijantimicag.2007.05.015
|
[150]
|
Hackstadt, T. and Williams, J.C. (1981) Biochemical Stratagem for Obligate Parasitism of Eukaryotic Cells by Coxiella burnetii. Proceedings of the National Academy of Sciences of the United States of America, 78, 3240-3244. https://doi.org/10.1073/pnas.78.5.3240
|
[151]
|
Ghigo, E., Capo, C., Aurouze, M., Tung, C.H., Gorvel, J.P., Raoult, D. and Mege, J.L. (2002) Survival of Tropheryma whipplei, the Agent of Whipple’s Disease, Requires Phagosome Acidification. Infection and Immunity, 70, 1501-1506. https://doi.org/10.1128/IAI.70.3.1501-1506.2002
|
[152]
|
Byrd, T.F. and Horwitz, M.A. (1991) Chloroquine Inhibits the Intracellular Multiplication of Legionella pneumophila by Limiting the Availability of Iron. A Potential New Mechanism for the Therapeutic Effect of Chloroquine against Intracellular Pathogens. The Journal of Clinical Investigation, 88, 351-357. https://doi.org/10.1172/JCI115301
|
[153]
|
Fortier, A.H., Leiby, D.A., Narayanan, R.B., et al. (1995) Growth of Francisella tularensis LVS in Macrophages: The Acidic Intracellular Compartment Provides Essential Iron Required for Growth. Infection and Immunity, 63, 1478-1483. https://doi.org/10.1128/IAI.63.4.1478-1483.1995
|
[154]
|
Raoult, D., Drancourt, M. and Vestris, G. (1990) Bactericidal Effect of Doxycycline Associated with Lysosomotropic Agents on Coxiella burnetii in P388D1 Cells. Antimicrobial Agents and Chemotherapy, 34, 1512-1514. https://doi.org/10.1128/AAC.34.8.1512
|
[155]
|
Maurin, M. and Raoult, D. (1994) Phagolysosomal Alkalinization and Intracellular Killing of Staphylococcus aureus by Amikacin. The Journal of Infectious Diseases, 169, 330-336. https://doi.org/10.1093/infdis/169.2.330
|
[156]
|
Nguyen, H.A., Grellet, J., Paillard, D., Dubois, V., Quentin, C. and Saux, M.C. (2006) Factors Influencing the Intracellular Activity of Fluoroquinolones: A Study Using Levofloxacin in a Staphylococcus aureus THP-1 Monocyte Model. Journal of Antimicrobial Chemotherapy, 57, 883-890. https://doi.org/10.1093/jac/dkl079
|
[157]
|
Eissenberg, L.G., Goldman, W.E. and Schlesinger, P.H. (1995) Histoplasma capsulatum Modulates the Acidification of Phagolysosomes. Journal of Experimental Medicine, 177, 1605-1611. https://doi.org/10.1084/jem.177.6.1605
|
[158]
|
Strasser, J.E., Newman, S.L., Ciraolo, G.M., Morris, R.E., Howell, M.L. and Dean, G.E. (1999) Regulation of the Macrophage Vacuolar ATPase and Phagosome-Lysosome Fusion by Histoplasma capsulatum. The Journal of Immunology, 162, 6148-6154.
|
[159]
|
Schafer, M.P. and Dean, G.E. (1993) Cloning and Sequence Analysis of an H+-ATPase-Encoding Gene from the Human Dimorphic Pathogen Histoplasma capsulatum. Gene, 136, 295-300. https://doi.org/10.1016/0378-1119(93)90483-J
|
[160]
|
Newman, S.L., Gootee, L., Brunner, G. and Deepe Jr., G.S. (1994) Chloroquine Induces Human Macrophage Killing of Histoplasma capsulatum by Limiting the Availability of Intracellular Iron and Is Therapeutic in a Murine Model of Histoplasmosis. The Journal of Clinical Investigation, 93, 1422-1429. https://doi.org/10.1172/JCI117119
|
[161]
|
Boelaert, J.R., Appelberg, R., Gomes, M.S., et al. (2001) Experimental Results on Chloroquine and AIDS-Related Opportunistic Infections. Journal of Acquired Immune Deficiency Syndrome, 26, 300-301. https://doi.org/10.1097/00126334-200103010-00017
|
[162]
|
Levitz, S.M., Harrison, T.S., Tabuni, A. and Liu, X. (1997) Chloroquine Induces Human Mononuclear Phagocytes to Inhibit and Kill Cryptococcus Neoformans by a Mechanism Independent of Iron Deprivation. The Journal of Clinical Investigation, 100, 1640-1646. https://doi.org/10.1172/JCI119688
|
[163]
|
Levitz, S.M., Nong, S.H., Seetoo, K.F., Harrison, T.S., Speizer, R.A. and Simons, E.R. (1999) Cryptococcus neoformans Resides in an Acidic Phagolysosome of Human Macrophages. Infection and Immunity, 67, 885-890. https://doi.org/10.1128/IAI.67.2.885-890.1999
|
[164]
|
Jahn, B., Langfelder, K., Schneider, U., Schindel, C. and Brakhage, A.A. (2002) PKSP-Dependent Reduction of Phagolysosome Fusion and Intracellular Kill of Aspergillus fumigatus Conidiabyhumanmonocyte-Derived Macrophages. Cellular Microbiology, 4, 793-803. https://doi.org/10.1046/j.1462-5822.2002.00228.x
|
[165]
|
Taramelli, D., Tognazioli, C., Ravagnani, F., Leopardi, O., Giannulis, G. and Boelaert, J.R. (2001) Inhibition of Intramacrophage Growth of Penicillium marneffei by 4-Aminoquinolines. Antimicrobial Agents and Chemotherapy, 45, 1450-1455. https://doi.org/10.1128/AAC.45.5.1450-1455.2001
|
[166]
|
Sieczkarski, S.B. and Whittaker, G.R. (2002) Dissecting Virus Entry via Endocytosis. Journal of General Virology, 83, 1535-1545. https://doi.org/10.1099/0022-1317-83-7-1535
|
[167]
|
Gonzalez-Dunia, D., Cubitt, B. and de la Torre, J.C. (1998) Mechanism of Borna Disease Virus Entry into Cells. Journal of Virology, 72, 783-788. https://doi.org/10.1128/JVI.72.1.783-788.1998
|
[168]
|
Shibata, M., Aoki, H., Tsurumi, T., Sugiura, Y., Nishiyama, Y., Suzuki, S. and Maeno, K. (1983) Mechanism of Uncoating of Influenza B Virus in MDCK Cells: Action of Chloroquine. Journal of General Virology, 64, 1149-1156. https://doi.org/10.1099/0022-1317-64-5-1149
|
[169]
|
Bishop, N.E. (1998) Examination of Potential Inhibitors of Hepatitis A Virus Uncoating. Intervirology, 41, 261-271. https://doi.org/10.1159/000024948
|
[170]
|
Miller, D.K. and Lenard, J. (1981) Antihistaminics, Local Anesthetics, and Other Amines as Antiviral Agents. Proceedings of the National Academy of Sciences, 78, 3605-3609. https://doi.org/10.1073/pnas.78.6.3605
|
[171]
|
Mizui, T., Yamashina, S., Tanida, I., Takei, Y., Ueno, T., Sakamoto, N., Ikejima, K., Kitamura, T., Enomoto, N., Sakai, T. and Kominami, E. (2010) Inhibition of Hepatitis C Virus Replication by Chloroquine Targeting Virus-Associated Autophagy. Journal of Gastroenterology, 45, 195-203. https://doi.org/10.1007/s00535-009-0132-9
|
[172]
|
Randolph, V.B., Winkler, G. and Stollar, V. (1990) Acidotropic Amines Inhibit Proteolytic Processing of Flavivirus prM Protein. Virology, 174, 450-458. https://doi.org/10.1016/0042-6822(90)90099-D
|
[173]
|
Savarino, A., Lucia, M.B., Rastrelli, E., Rutella, S., Golotta, C., Morra, E., Tamburrini, E., Perno, C.F., Boelaert, J.R., Sperber, K. and Cauda, R. (2004) Anti-HIV Effects of Chloroquine: Inhibition of Viral Particle Glycosylation and Synergism with Protease Inhibitors. JAIDS Journal of Acquired Immune Deficiency Syndromes, 35, 223-232. https://doi.org/10.1097/00126334-200403010-00002
|
[174]
|
Naarding, M.A., Baan, E., Pollakis, G. and Paxton, W.A. (2007) Effect of Chloroquine on Reducing HIV-1 Replication in Vitro and the DC-SIGN Mediated Transfer of Virus to CD4+T-Lymphocytes. Retrovirology, 4, Article No.: 6. https://doi.org/10.1186/1742-4690-4-6
|
[175]
|
Kwiek, J.J., Haystead, T.A. and Rudolph, J. (2004) Kinetic Mechanism of Quinone Oxidoreductase 2 and Its Inhibition by the Antimalarial Quinolines. Biochemistry, 43, 4538-4547. https://doi.org/10.1021/bi035923w
|
[176]
|
Devaux, C.A., Rolain, J.M., Colson, P. and Raoult, D. (2020) New Insights on the Antiviral Effects of Chloroquine against Coronavirus: What to Expect for COVID-19? International Journal of Antimicrobial Agents, 55, 105938. https://doi.org/10.1016/j.ijantimicag.2020.105938
|
[177]
|
Savarino, A., Di Trani, L., Donatelli, I., Cauda, R. and Cassone, A. (2006) New Insights into the Antiviral Effects of Chloroquine. The Lancet Infectious Diseases, 6, 67-69. https://doi.org/10.1016/S1473-3099(06)70361-9
|
[178]
|
Savarino, A., Boelaert, J.R., Cassone, A., Majori, G. and Cauda, R. (2003) Effects of Chloroquine on Viral Infections: An Old Drug against Today’s Diseases. The Lancet Infectious Diseases, 3, 722-777. https://doi.org/10.1016/S1473-3099(03)00806-5
|
[179]
|
Keyaerts, E., Li, S., Vijgen, L., Rysman, E., Verbeeck, J., Van Ranst, M. and Maes, P. (2009) Antiviral Activity of Chloroquine against Human Coronavirus OC43 Infection in Newborn Mice. Antimicrobial Agents and Chemotherapy, 53, 3416-3421. https://doi.org/10.1128/AAC.01509-08
|
[180]
|
Gorbalenya, A.E., Snijder, E.J. and Spaan, W.J. (2004) Severe Acute Respiratory Syndrome Coronavirus Phylogeny: Toward Consensus. Journal of Virology, 78, 7863-7866. https://doi.org/10.1128/JVI.78.15.7863-7866.2004
|
[181]
|
Keyaerts, E., Vijgen, L., Maes, P., Neyts, J. and Van Ranst, M. (2004) In Vitro Inhibition of Severe Acute Respiratory Syndrome Coronavirus by Chloroquine. Biochemical and Biophysical Research Communications, 323, 264-268. https://doi.org/10.1016/j.bbrc.2004.08.085
|
[182]
|
Colson, P., Rolain, J.M. and Raoult, D. (2020) Chloroquine for the 2019 Novel Coronavirus SARS-CoV-2. International Journal of Antimicrobial Agents, 55, 105923. https://doi.org/10.1016/j.ijantimicag.2020.105923
|
[183]
|
Jeevaratnam, K. (2020) Chloroquine and Hydroxychloroquine for COVID-19: Implications for Cardiac Safety. European Heart Journal—Cardiovascular Pharmacotherapy.
|
[184]
|
Gendrot, M., Javelle, E., Le Dault, E., Clerc, A., Savini, H. and Pradines, B. (2020) Chloroquine as Prophylactic Agent against COVID-19? International Journal of Antimicrobial Agents, 55, 105980. https://doi.org/10.1016/j.ijantimicag.2020.105980
|
[185]
|
Yazdany, J. and Kim, A.H. (2020) Use of Hydroxychloroquine and Chloroquine during the COVID-19 Pandemic: What Every Clinician Should Know. Annals of Internal Medicine, 172, 754-755.
|
[186]
|
Wang, P.H. (2020) Increasing Host Cellular Receptor—Angiotensin-Converting Enzyme 2 (ACE2) Expression by Coronavirus May Facilitate 2019-nCoV Infection. BioRxiv, preprint. https://doi.org/10.1101/2020.02.24.963348
|
[187]
|
Zhang, C., Wu, Z., Li, J.W., Zhao, H. and Wang, G.Q. (2020) The Cytokine Release Syndrome (CRS) of Severe COVID-19 and Interleukin-6 Receptor (IL-6R) Antagonist Tocilizumab May Be the Key to Reduce the Mortality. International Journal of Antimicrobial Agents, 55, 105954. https://doi.org/10.1016/j.ijantimicag.2020.105954
|
[188]
|
Golden, E.B., Cho, H.-Y., Hofman, F.M., Louie, S.G., Schonthal, A.H. and Chen, T.C. (2015) Quinoline-Based Antimalarial Drugs: A Novel Class of Autophagy Inhibitors. Neurosurgical Focus, 38, E12. https://doi.org/10.3171/2014.12.FOCUS14748
|
[189]
|
Vincent, M.J., Bergeron, E., Benjannet, S., Erickson, B.R., Rollin, P.E., Ksiazek, T.G., Seidah, N.G. and Nichol, S.T. (2005) Chloroquine Is a Potent Inhibitor of SARS Coronavirus Infection and Spread. Virology Journal, 2, Article No. 69. https://doi.org/10.1186/1743-422X-2-69
|
[190]
|
Masmoudi, A., Abdelmaksoud, W., Turki, H., Hachicha, M., Marrekchi, S., Mseddi, M., Bouassida, S. and Zahaf, A. (2006) Beneficial Effects of Antimalarials in the Treatment of Generalized Granuloma Annular in Children. La Tunisie Medicale, 84, 125-127.
|
[191]
|
Wolverton, J.E., Soter, N.A. and Cohen, D.E. (2014) The Natural History of Chronic Actinic Dermatitis: An Analysis at a Single Institution in the United States. Dermatitis, 25, 27-31. https://doi.org/10.1097/DER.0000000000000007
|
[192]
|
Schultz, K.R., Su, W.N., Hsiao, C.C., Doho, G., Jevon, G., Bader, S., MacFarlane, D.E. and Gilman, A.L. (2002) Chloroquine Prevention of Murine MHC-Disparate Acute Graft-versus-Host Disease Correlates with Inhibition of Splenic Response to CpG Oligodeoxynucleotides and Alterations in T-Cell Cytokine Production. Biology of Blood and Marrow Transplantation, 8, 648-655. https://doi.org/10.1053/bbmt.2002.v8.abbmt080648
|
[193]
|
Company-Quiroga, J., Alique-García, S. and Romero-Maté, A. (2019) Current Insights into the Management of Discoid Lupus Erythematosus. Clinical, Cosmetic and Investigational Dermatology, 12, 721.
|
[194]
|
Ashton, R.E., Hawk, J.L. and Magnus, I.A. (1984) Low-Dose Oral Chloroquine in the Treatment of Porphyria Cutanea Tarda. British Journal of Dermatology, 111, 609-613. https://doi.org/10.1111/j.1365-2133.1984.tb06632.x
|
[195]
|
Murphy, G.M., Hawk, J.L. and Magnus, I.A. (1987) Hydroxychloroquine in Polymorphic Light Eruption: A Controlled Trial with Drug and Visual Sensitivity Monitoring. British Journal of Dermatology, 116, 379-386. https://doi.org/10.1111/j.1365-2133.1987.tb05852.x
|
[196]
|
Callen, J.P. (1985) Dermatomyostis—An Update 1985. Seminars in Dermatology, 4, 114-125.
|
[197]
|
Balogh, E., Nagy-Vezekenyi, K. and Forizs, E. (1980) REM Syndrome: An Immediate Therapeutic Response to Hydroxychloroquine Sulphate. Acta Dermato-Venereologica, 60, 173-175.
|
[198]
|
Toonstra, J., Wildschut, A., Boer, J., Smeenk, G., Willemze, R., van der Putte, S.C., Boonstra, H. and van Vloten, W.A. (1989) Jessner’s Lymphocytic Infiltration of the Skin: A Clinical Study of 100 Patients. Archives of Dermatology, 125, 1525-1530. https://doi.org/10.1001/archderm.1989.01670230067010
|
[199]
|
Mathews-Roth, M.M. (1986) Systemic Photoprotection. Dermatologic Clinics, 4, 335-339. https://doi.org/10.1016/S0733-8635(18)30837-4
|
[200]
|
Swanbeck, G. (1982) Treatment of Photodermatoses. Seminars in Dermatology, 1, 211-216.
|
[201]
|
Jones, E. and Callen, J.P. (1990) Hydroxychloroquine Is Effective Therapy for Control of Cutaneous Sarcoidal Granulomas. Journal of the American Academy of Dermatology, 23, 487-489. https://doi.org/10.1016/0190-9622(90)70246-E
|
[202]
|
Carlin, M.C. and Ratz, J.L. (1987) A Case of Generalized Granuloma Annulare Responding to Hydroxychloroquine. Cleveland Clinic Journal of Medicine, 54, 229-232.
|
[203]
|
Liedtka, J.E. (1996) Intralesional Chloroqnine for the Treatment of Cutaneous Sarcoidosis. International Journal of Dermatology, 35, 682-683. https://doi.org/10.1111/j.1365-4362.1996.tb03710.x
|
[204]
|
Wolverton, S.E. and Wilkin, J.K., Eds. (1991) Systemic Drugs for Skin Diseases. WB Saunders Company, Philadelphia.
|
[205]
|
Geamanu, A., Popa-Cherecheanu, A., Marinescu, B., et al. (2014) Retinal Toxicity Associated with Chronic Exposure to Hydroxychloroquine and Its Ocular Screening. Journal of Medicine and Life, 7, 322-326.
|
[206]
|
Stelton, C.R., Connors, D.B., Walia, S.S. and Walia, H.S. (2013) Hydrochloroquine Retinopathy: Characteristic Presentation with Review of Screening. Clinical Rheumatology, 32, 895-898. https://doi.org/10.1007/s10067-013-2226-2
|
[207]
|
Yogasundaram, H., Putko, B.N., Tien, J., Paterson, D.I., Cujec, B., Ringrose, J. and Oudit, G.Y. (2014) Hydroxychloroquine-Induced Cardiomyopathy: Case Report, Pathophysiology, Diagnosis, and Treatment. Canadian Journal of Cardiology, 30, 1706-1715. https://doi.org/10.1016/j.cjca.2014.08.016
|
[208]
|
Bortoli, R. and Santiago, M. (2007) Chloroquine Ototoxicity. Clinical Rheumatology, 26, 1809-1810. https://doi.org/10.1007/s10067-007-0662-6
|
[209]
|
Coutinho, M.B. and Duarte, I. (2002) Hydroxychloroquine Ototoxicity in a Child with Idiopathic Pulmonary Haemosiderosis. International Journal of Pediatric Otorhinolaryngology, 62, 53-57. https://doi.org/10.1016/S0165-5876(01)00592-4
|
[210]
|
Tonnesmann, E., Kandolf, R. and Lewalter, T. (2013) Chloroquine Cardiomyopathy—A Review of the Literature. Immunopharmacology and Immunotoxicology, 35, 434-442. https://doi.org/10.3109/08923973.2013.780078
|
[211]
|
Joyce, E., Fabre, A. and Mahon, N. (2013) Hydroxychloroquine Cardiotoxicity Presenting as a Rapidly Evolving Biventricular Cardiomyopathy: Key Diagnostic Features and Literature Review. European Heart Journal: Acute Cardiovascular Care, 2, 77-83. https://doi.org/10.1177/2048872612471215
|
[212]
|
Martins, A.C., Cayotopa, A.D., Klein, W.W., Schlosser, A.R., Silva, A.F., Souza, M.N., Andrade, B.W., Filgueira-Júnior, J.A., Pinto, W.D. and da Silva-Nunes, M. (2015) Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mancio Lima, Acre, Brazil). Interdisciplinary Perspectives on Infectious Diseases, 2015, Article ID: 346853. https://doi.org/10.1155/2015/346853
|
[213]
|
Van Beek, M.J. and Piette, W.W. (2001) Antimalarials. Dermatologic Clinics, 19, 147-160. https://doi.org/10.1016/S0733-8635(05)70236-9
|
[214]
|
Onyeji, C.O. and Ogunbona, F.A. (2001) Pharmacokinetic Aspects of Chloroquine-Induced Pruritus: Influence of Dose and Evidence for Varied Extent of Metabolism of the Drug. European Journal of Pharmaceutical Sciences, 13, 195-201. https://doi.org/10.1016/S0928-0987(01)00108-7
|
[215]
|
Bolanos-Meade, J., Zhou, L., Hoke, A., Corse, A., Vogelsang, G. and Wagner, K.R. (2005) Hydroxychloroquine Causes Severe Vacuolar Myopathy in a Patient with Chronic Graft-versus-Host Disease. American Journal of Hematology, 78, 306-309. https://doi.org/10.1002/ajh.20294
|
[216]
|
Tristano, A.G., Falcón, L., Willson, M. and de Oca, I.M. (2004) Seizure Associated with Chloroquine Therapy in a Patient with Systemic Lupus Erythematosus. Rheumatology International, 24, 315-316. https://doi.org/10.1007/s00296-003-0435-8
|
[217]
|
Sharma, N. and Varma, S. (2003) Unusual Life-Threatening Adverse Drug Effects with Chloroquine in a Young Girl. Journal of Postgraduate Medicine, 49, 187.
|