Author(s)

I. Akinlua^*, M. F. Asaolu, O. C. Ojo, G. O. Oyebanji

Biochemistry Department, Ekiti State University, Ado Ekiti, Nigeria.

Stroke is a leading cause of morbidity and mortality worldwide. Oxidative stress which is as a result of increased activity of free radicals and decreased antioxidant mechanism plays a major role in the pathogenesis of stroke. This study determined the plasma level of malondialdehyde (MDA), a marker of lipid peroxidation and oxidative stress and enzymatic Antioxidants namely, superoxide dismutase (SOD), Glutathione peroxidase (GPx), and Catalase (CAT) in sixty stroke patients of both sexes attending Wesley Guide Hospital, Obafemi Awolowo University Teaching Hospital, Ilesa, Osun State. An equal number of healthy subjects were used as control. The result of this study revealed a significantly (p < 0.05) high plasma level of MDA in stroke patients when compared with the control subjects. Plasma level of SOD in stroke patients was significantly higher (p < 0.05) than the control subjects while plasma GPx and CAT level were found to be significantly lower (p < 0.05) in stroke patients than the control subjects. The result of the study indicated high level of lipid peroxidation and oxidative stress in stroke patients and high degree of free radicals presence as indicated by the high level of SOD.

Stroke, Malondialdehyde, Catalase, Superoxide Dismutase, Glutathione Peroxidase, Lipid Peroxidation

Akinlua, I. , Asaolu, M. , Ojo, O. and Oyebanji, G. (2019) Evaluation of Oxidative Stress and Antioxidant Level of Stroke Patients in Osun State, South-Western Nigeria. Journal of Biosciences and Medicines, 7, 189-194. doi: 10.4236/jbm.2019.75020.