Author(s)

Akira Iizuka^1*, Maasa Sonoda², Ruka Goto², Tokunori Matsui³, Chiaki Kudoh⁴, Katsumi Kido⁵, Yasuhiro Komatsu³

¹Center for Supporting Pharmaceutical Education, Daiich University of Pharmacy, Fukuoka, Japan.
²Clinical Pharmacy Education Center, Japan College of Pharmaceutical Science, Saitama, Japan.
³Sun R and D Institute for Natural Medicines Co., Inc., Tokyo, Japan.
⁴KUDOH CHIAKI Clinic for Neurosurgery & Neurology, Tokyo Brain & Spinal Cord Research Institute, Tokyo, Japan.
⁵Department of Pharmacognosy, Daiich University of Pharmacy, Fukuoka, Japan.

SRD-P401 is a newly developed healthy food supplement which has an anti-inflammatory and analgesic effect. In this report, the effects of SRD-P401 on neck and shoulder stiffness were assessed by an inquiry method in the public field. The stiffness symptoms of all participants were improved after taking SRD-P401. The symptoms of the participants who took 3 g/day and/or 9 g/day of SRD-P401 improved in a week after taking it. Unpleasant adverse effects in stomach and alimentally organs were not found during the test period. SRD-P401 showed the anti-nociceptive effect on the acetic-acid-induces abdominal writhing in rats. The potency was equivalent to aspirin. Moreover, to investigate the ability of the anti-inflammatory effects of SRD-P401, we exerted by inhibiting the Cyclooxygenase (COX) enzyme activity. SRD-P401 and its constituents inhibit the COX activity. The results of this field test indicated SRD-P401 would be a beneficial and useful healthy food supplement for a person with stiffness in neck and/or shoulder.

Supplement, Anti-Inflammatory, Anti-Nociceptive, SRD-P401

Iizuka, A. , Sonoda, M. , Goto, R. , Matsui, T. , Kudoh, C. , Kido, K. and Komatsu, Y. (2017) Effect of SRD-P401 on the Discomfort of Neck and/or Shoulder Stiffness. American Journal of Plant Sciences, 8, 1065-1076. doi: 10.4236/ajps.2017.85070.