A New Dolabrane Dinorditerpene from Ceriops tagal - Open Access Library Journal

OALibJ > Vol.3 No.8, August 2016

Open Access Library Journal

Volume 3, Issue 8 (August 2016)

ISSN Print: 2333-9705 ISSN Online: 2333-9721

Google-based Impact Factor: 0.73 Citations

A New Dolabrane Dinorditerpene from Ceriops tagal ()

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DOI: 10.4236/oalib.1102957 1,106 Downloads 1,844 Views Citations

Author(s)

Xin Wu¹, Hongbo Liao^2*, Hongyu Lu^3,4, Chaohua Zhang^3,4

Affiliation(s)

¹Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, China.
²Department of Pharmacology, Guangdong Medical University, Zhanjiang, China.
³Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Ocean University, Zhanjiang, China.
⁴Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Guangdong Ocean University, Zhanjiang, China.

ABSTRACT

A new dolabrane dinorditerpene, tagalsine X(1), was isolated from the leaves of Ceriops tagal, along with five known analogues (2-6). Their structures were established on the basis of spectroscopic data or comparison with the literatural data. Their cytotoxic activities against four human carcinoma cell lines (CNE-2, HCT-116, HepG2and A549) were also evaluated, which displayed that only compound 2 had significant cytotoxicity against those cell lines with IC50 values of 13.57, 42.32, 11.21 and 15.23 μM, respectively.

KEYWORDS

Ceriops tagal, Dolabrane, Tagalsine X, Cytotoxicity

Share and Cite:

Wu, X. , Liao, H. , Lu, H. and Zhang, C. (2016) A New Dolabrane Dinorditerpene from Ceriops tagal. Open Access Library Journal, 3, 1-6. doi: 10.4236/oalib.1102957.

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