Author(s)

Amany M. Eida^1*, Omima M. Eida¹, Ahmed Saied Salem²

¹Department of Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
²Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Trichomoniasis is most common sexually transmitted disease caused by T. vaginalis. The clinical manifestation varies from severe manifestation to asymptomatic condition. However, the exact virulence markers led to varied symptomatology was not well clarified. The role of leukotriene B₄ (LTB₄) in the pathogenesis of many parasitic diseases has been reported. The present study reports the leukotriene B₄ levels on different days post infection (3rd, 7th, 14th, 21st and 28th d.p.i.) in serum and vaginal washes (VWs) and vaginal tissues of mice infected intravaginally with T. vaginalis isolates from 10 symptomatic and 10 asymptomatic women. A significant increase in LTB₄ was observed on the 3rd to 28th d.p.i. in serum and VWs of mice infected with T. vaginalis isolates from asymptomatic as compared to symptomatic women. The present study also reports the histopathological changes of the posterior vaginal fornix’s and upper portion of the vagina of mice infected intravaginally with T. vaginalis isolates from 10 symptomatic and 10 asymptomatic women. The results show that there are no significant differences between symptomatic and asymptomatic isolates regarding histopathological changes.

Trichomoniasis, Clinical Isolates, Experimental Study, Pathogenesis, Immune Response, Leukotriene B₄

Eida, A. , Eida, O. and Salem, A. (2015) Kinetics of Serum and Local Leukotriene B₄ Response in Experimental Intravaginal Trichomoniasis by T. vaginalis Isolates from Symptomatic and Asymptomatic Women. Advances in Infectious Diseases, 5, 37-47. doi: 10.4236/aid.2015.51004.