Background: Era of
contraception, abortions, [20th, 21st centuries] implemented as family welfare
schemes witnessed, increased global incidence of cancer, tumors, neoplasm and
mortality. Objectives: Altruistic association of contraception [if any], with
increasing cancer, tumor was sought after. Methods: In 2012, retrospective
analysis of, prevalence of cancer, tumor in 350 patients of 20 - 35 years, 35 -
50 years, >50 years age groups, from data collected by convenient,
stratified random sampling, from different geographical locations, between
2002-2012 and its association with presence, absence of contraception, abortion
was undertaken; simultaneously, serum estrogen levels obtained from 105 patients,
were also analyzed. From 1983-2012 clinical practice, 212 patients treated for
different types of neoplasm namely breast cancer, prostate cancer, cancer
cervix and benign prostatic hyperplasia were randomly allotted to the above 3
age groups and the data were analyzed for association with contraception status
and possible significance. Results: 6 fold increase in cancer incidence was
seen in contraceptive users among >50 years with a p value of <0.0005. Contraception
was associated with 4 - 7 fold increase in tumor prevalence among >35 - >50
years with a p value of <0.0005. Endogenous estrogen had decreased to ~5-8
pg in 61% of contraceptive users with a p value of <0.0005; after
hysterectomy endogenous estrogen values up to ~0.4 pg were seen. Cholesterol
deprived diet, due to decreased synthesis of endogenous estrogen:androgen also
was associated with 50% increase in tumor, cancer in youth without contraception.
Estrogen receptors were positive in well differentiated cancers of breast,
associated with reduced levels of endogenous estrogen among contraceptive
users, suggesting estrogen receptor positivity could be a compensatory
phenomenon; anaplastic tumors did not exhibit estrogen receptor positivity. 10 -
20 fold increase in breast cancer was seen among 20 - >50 years, in contraceptive
users with a p value of <0.0005; 20 - 30 fold increase in prostate cancer
was seen among 35 - >50 years, in contraceptive users with a p value of
<0.0005; cancer of the cervix had increased 20 - 40 fold, among 20 - 70
years, in contraceptive users with a p value of <0.0005. Conclusion: Concept
is acquired contraception preventing traversal of normal path by germ cells
with resultant smashed destruction of germ cells, consequent reduced endogenous
estrogen:androgen surveillance, leading to agonizing faults of cellular genomic
repertoire, uncontrolled multiplication preceded by no differentiation of cell
cycle, metabolism, resulting in soaringly high incidence of cancers including
breast, prostate and uterine cervix in both life partners. Increased estrogen receptors:androgen
receptors in breast, prostate well differentiated cancers respectively are, probably
a compensatory rise, secondary to the sudden artificially acquired
contraception resulting in significant reduction of endogenous germ cell
hormones in contraceptive users. Contraception reversal with chemotherapy,
radiation therapy, surgery achieves arrest of progression of cancer, reduces
incidence, prevalence of neoplasm, as a cause-effect phenomenon and not
castration or anti estrogen:antiandrogens which will perpetuate, promote
neoplastic diseases by decreasing endogenous estrogen:androgen.