In this paper, we introduce some new classes of the totally quasi-G-asymptotically nonexpansive mappings and the totally quasi-G-asymptotically nonexpansive semigroups. Then, with the generalized f-projection operator, we prove some strong convergence theorems of a new modified Halpern type hybrid iterative algorithm for the totally quasi-G-asymptotically nonexpansive semigroups in Banach space. The results presented in this paper extend and improve some corresponding ones by many others.