Mathematical Modeling of Hemoglobin Release under Hypotonic Conditions - Engineering

ENG > Vol.4 No.10, October 2012

Engineering

Volume 4, Issue 10 (October 2012)

ISSN Print: 1947-3931 ISSN Online: 1947-394X

Google-based Impact Factor: 0.66 Citations

Mathematical Modeling of Hemoglobin Release under Hypotonic Conditions ()

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DOI: 10.4236/eng.2012.410B046 3,033 Downloads 4,059 Views Citations

Author(s)

Ivana Pajic-Lijakovic, Branko Bugarski, Milenko Plavsic

Affiliation(s)

Dept. of Chem. Eng. University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia.
Dept. of Polymer Eng., University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia.

ABSTRACT

Mathematical model is developed to estimate hemoglobin release under hypotonic conditions at microscopic level. The phenomenon of hemoglobin (Hb) release depends on: 1) the dynamics of repeated opening of hemolytic holes and 2) the radial fluctuations of lipid membrane. Both processes are sensitive to the rate of ionic strength decrease within the surrounding medium. Influence of the rate of ionic strength decrease on hemoglobin release is quantified by the model parameters: 1) the specific decrease of erythrocyte radius and 2) the specific decrease of hole radius during single opening time period of hemolytic hole. The prediction of released amount of Hb influenced by the conductive mechanism is equal to 2.9 %. The prediction of total released amount of Hb influenced by the conductive and convective mechanisms is approximately equal to 4 % of the initial amount of Hb within erythrocyte.

KEYWORDS

Hemoglobin Transport; Hemolytic Hole; Thermodynamics; Cellular Biology and Engineering; Mathematical Modeling

Share and Cite:

I. Pajic-Lijakovic, B. Bugarski and M. Plavsic, "Mathematical Modeling of Hemoglobin Release under Hypotonic Conditions," Engineering, Vol. 4 No. 10B, 2012, pp. 176-179. doi: 10.4236/eng.2012.410B046.

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