Background: The association between uric acid (UA) with metabolic syndrome (MS) has been researched more in adults than in adolescents. In fact, this association is not completely understood among adolescents. Objectives: The purpose of this study was to explore the association between UA with MS. Methods: A cross-sectional sample of 742 Kuwaiti adolescents (303 males and 439 females) who were apparently healthy, chosen from randomly selected schools were used for the study; four intermediate (two males and two females) and four secondary (two males and two females) schools. Results: The results of the study showed the UA level was highly associated with MS, especially among males. UA was significantly associated with each of the six parameters of MS. Conclusions: The level of uric acid among the adolescent was high and it was significantly associated with MS and gender. Dietary interventions are necessary to reduce UA and the parameters of MS among the adolescents.