Author(s)

Euslar Nnenna Onu^1*, Donatus Chukwuma Ilang¹, Cornelius Ituma Azi², Theophilus Onwe Eze³, Chinedu Obasi Akpa⁴, Oluwatoyin Oluwatosin Kelechi-Mathew¹, Okechukwu Emmanuel Ogbonna⁵, Samuel Eleojo Agada⁶

¹Department of Microbiology, Faculty of Biological Sciences, Alex-Ekwueme Federal University Ndufu-Alike, Ikwo, Ebonyi State, Nigeria.
²Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom.
³Park Hospital Burntstump Country Park, Nottingham, United Kingdom.
⁴Department of Haematology, Faculty of Basic Clinical Sciences, Alex-Ekwueme Federal University Ndufu-Alike, Ikwo, Abakaliki, Nigeria.
⁵Department of Stems and Regenerative Medicine, University of Chester, Chester, United Kingdom.
⁶Department of Biotechnology, University of Chester, Chester, United Kingdom.

Antibiotic-resistant genes have become a threat to synthetic or conventional medications and because of this much work has been done on using plants and plants part to treat disease caused by bacteria, Herbal medicine has served as effective treatment against various diseases caused by pathogenic bacteria and multi drug-resistant strains of bacteria which made it advantageous over synthetic medications. This study aimed to reveal the sensitivity of Streptococcus pneumoniae from clinical isolate and perform antibacterial assay on the organism using plants leaf extracts of Ocimum gratissimum, Sida acuta, Newbouldia laevia and Mimosa pudica. Gram staining and various biochemical test were used for the identification of Streptococcus pneumoniae. The plants leaves were aseptically washed, dried and ground into fine powder and diluted in varying concentration and agar well diffusion method was used to test for the antimicrobial properties of this plants on Streptococcus pneumoniae at various concentrations as follows 0.1 g/ml, 0.4 g/ml, 0.6 g/ml and 1 g/ml. The plants extract of Ocimum gratissimum showed a greater antibacterial effects on Streptococcus pneumoniae in high concentration more than other plant extracts while Sida acuta and Newbouldia laevia plant extract showed weak antibacterial properties to the organism. This proves that Ocimum gratissimum and Mimosa pudica leaves have good and strong antibacterial properties against Streptococcus pneumoniae than Sida acuta and Newbouldia laevia and can be used as antibacterial agent at adequate concentrations.

Conventional, Herbal, Antibacterial, Extracts, Concentrations

Onu, E. , Ilang, D. , Azi, C. , Eze, T. , Akpa, C. , Kelechi-Mathew, O. , Ogbonna, O. and Agada, S. (2024) Antimicrobial Activities of Plant Extracts against Streptococcus pneumoniae Isolated from Pediatric Patients at Federal Teaching Hospital Abakaliki, Ebonyi State. American Journal of Plant Sciences, 15, 847-857. doi: 10.4236/ajps.2024.1510054.