Author(s)

Yang Yang¹, Pascale Kulisa², Benyebka Bou-Saïd^1,3, Mahmoud El Hajem⁴, Serge Simoens², Nellie Della Schiava⁵

¹CNRS, INSA de Lyon, LaMCoS, University of Lyon, Villeurbanne, France.
²INSA Lyon, CNRS, Ecole Centrale de Lyon, Univ Claude Bernard Lyon 1, LMFA, University of Lyon, Villeurbanne, France.
³State Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials, Northwestern Poytechnical University, Xi’an, China.
⁴CNRS, Ecole Centrale de Lyon, INSA Lyon, Univ Claude Bernard Lyon 1, LMFA, University of Lyon, Ecully, France.
⁵Department of Vascular Surgery, Hospices Civils de Lyon, Lyon, France.

In dialysis treatment, the radio-cephalic arteriovenous fistula (RCAVF) is a commonly used fistula, yet its low maturation rate remains a challenge. To enhance surgical outcomes, the relationship between stenosis-prone locations and RCAVF anastomosis angle is studied during maturation by developing two sets of RCAVF models for early (non-mature) and mature RCAVFs at five anastomosis angles. The impact of hemodynamics and wall shear stress (WSS) is examined to determine optimal anastomotic angles. Results indicate that acute angles produce more physiological WSS distributions and fewer disturbed regions, with early stenosis-prone regions located near the anastomosis that shift to the bending venous segment during remodeling. A pilot study comparing clinical and numerical results is conducted for validation.

Radio-Cephalic Arteriovenous Fistula (RCAVF), Anastomosis Angle, Maturation, Wall Shear Stress Distribution, Stenosis-Prone Locations

Yang, Y. , Kulisa, P. , Bou-Saïd, B. , El Hajem, M. , Simoens, S. and Schiava, N. (2023) A Computational Analysis of the Influence of Anastomosis Angle on Stenosis-Prone Locations during Radio-Cephalic Arteriovenous Fistula Maturation. Journal of Biomedical Science and Engineering, 16, 81-93. doi: 10.4236/jbise.2023.166006.