Chronic Viral Hepatitis C: Before and after Direct Acting Antivirals (DAA) in Morocco ()
Author(s)
Hakima Abid1,2,3,
Maryam Khayari1,2,3,
Hajar Cherkaoui1,2,3,
Maria Lahlali1,2,3,
Nada Lahmidani1,
Mounia Elyousfi1,2,3,
Nourdin Aqodad4,5,
Sidi Adil Ibrahimi1,2,3,
Mohamed El Abkari1,2,3
Affiliation(s)
1Hepato-Gastroenterology Unit, University Hospital Hassan II, Fez, Morocco.
2Laboratory of Human Pathology, Biomedicine and Environment, Fez, Morocco.
3Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
4Hepato-Gastroenterology Unit, University Hospital Ibn Zohr, Agadir, Morocco.
ABSTRACT
For a long time, a combination of interferon and ribavirin has been used
to
treat viral hepatitis C, but the
sustained virological response was only achieved in 45% of cases and
side effects were serious
[1]. Direct acting antivirals (DAA) have provided a cure for almost everyone
with hepatitis C, with few side effects. The Purpose of Our Work is to
compare the results of treatment for viral hepatitis C before and after DAA. Patients
and Methods: This
is a retrospective study, bringing together all patients with chronic viral
hepatitis C treated between January 2009 and March 2020 at the University
Hospital Hassan II in Fez, Morocco. The epidemiological, clinical, biological,
virological characteristics of the included patients were collected from the
two groups: A, treated with interferon and ribavirin or by triple therapy and
B, treated with DAA. Results: 162 patients were included, the average age was 55 y/o, with 90 women
and 72 men. 88 patients (54.3%) were already cirrhotic, of which 61 were
compensated and 27 were decompensated. Genotype 1 was dominant with a frequency
of 71.6%, 107 patients (66%) initially treated with old HCV treatments and 55
(34%) treated with DAA. Sustained viral response was obtained in 59 cases
(55.14%) in group A versus 54 cases (98.18%) in group B with a very significant
difference (p < 0.0001). Treatment failure was observed in 14 patients
(13.1%) in group A and only one patient, i.e. 2% in group B (p = 0.019). 14 patients relapsed in group A (13.1%) versus 0
patient in group B (p = 0.003). The tolerance of the treatment was excellent in
group B as a whole with only five patients (9%) reported side effects which
were minor, not leading to the discontinuation of treatment while the side
effects were major in 49 patients (45.7%) in group A with led to the permanent
discontinuation of treatment in 6 patients. The difference in side effects
between the two groups was very significant with (p < 0.0001). Conclusion:
Our study has shown the superiority of DAA in terms of efficacy and tolerance
compared to the old treatments for chronic hepatitis C. In addition, these
treatments allow almost systematic viral elimination and therefore consequently
a reduction in the risk of complications hepatic with a short time of treatment.
Share and Cite:
Abid, H. , Khayari, M. , Cherkaoui, H. , Lahlali, M. , Lahmidani, N. , Elyousfi, M. , Aqodad, N. , Ibrahimi, S. and El Abkari, M. (2022) Chronic Viral Hepatitis C: Before and after Direct Acting Antivirals (DAA) in Morocco.
Open Journal of Gastroenterology,
12, 55-63. doi:
10.4236/ojgas.2022.123006.
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