Author(s)

Yu Cai^1*, Jianjun Zhai¹, Bibo Feng¹, Rui Chen², Xingyue Tian¹

¹Department of Gynecology and Obstetrics, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China.
²Department of Laboratory Medicine, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China.

Objective: To investigate the effect of aspirin on pregnancy outcome and serum levels of endothelin-1 (ET-1) and thrombomodulin (TM) in pregnancy patients with chronic hypertension. Methods: Selected patients with chronic hypertension (mild to moderate) during pregnancy, who were enrolled and delivered in the Beijing Tongren Hospital Department of Obstetrics and Gynecology between January 1, 2019 and December 30, 2020. The patients were randomly divided into control group (60) and experimental group (60). The control group was treated with labetalol and the test group was treated with labetalol and aspirin. The therapeutic effect and pregnancy outcome of the two groups were compared. The serum levels of ET-1 and TM were measured before treatment and one week after treatment. Results: Systolic blood pressure (SBP) decreased significantly one week after treatment in the two groups (P < 0.05). One week after treatment, the values of ET-1 and TM in the experimental group were significantly lower than those in the Control Group, the difference is statistically significant (P < 0.05). The incidence of Preeclampsia, intrauterine growth retardation, oligohydramnios, placental abruption, Cesarean section and preterm birth in the experimental group was significantly lower than that in the control group. There was significant difference between the two groups, especially Preeclampsia and Intrauterine Growth Retardation (P < 0.05). Conclusion: Besides routine treatment, aspirin can improve the outcome of pregnant women with chronic hypertension, which may be related to the regulation of ET-1 and TM by aspirin.

Pregnancy with Chronic Hypertension, Aspirin, Maternal and Fetal Outcomes, ET-1, TM

Cai, Y. , Zhai, J. , Feng, B. , Chen, R. and Tian, X. (2021) Effects of Aspirin on Pregnancy Outcome and Serum Endothelin-1 and Thrombomodulin Levels in Pregnancy Patients with Chronic Hypertension. Open Journal of Obstetrics and Gynecology, 11, 1073-1080. doi: 10.4236/ojog.2021.118100.