Author(s)

Tuo Nanou Tiéba¹, Kangah Niameke Jean Baptiste¹, Ballo Daouda^2,3, Kablan Ahmont Landry Claude⁴, Kodjo Charles Guillaume¹, Yapo Ossey Bernard^5,6, Ziao Nahossé¹

¹Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Université NanguiAbrogoua, Abidjan, Côte d’Ivoire.
²Laboratoire de Chimie Organique Heterocyclique URAC 21, Pôle de Compétence Pharmacochimie, Faculté des Sciences, Université’ Mohammed V, Rabat, Moroc.
³Laboratoire de Constitution et Réaction de la Matière (LCRM), UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire.
⁴UFR Des Sciences Biologiques, Université Péléforo Gon Coulibaly de Korhogo, Korhogo, Côte d’Ivoire.
⁵Laboratoire Centrale de l’Environnement (LCE), Centre Ivoirien Antipollution (CIAPOL), Abidjan, Côte d’Ivoire.
⁶Laboratoire des Sciences de l’Environnement (LSE), UFR SGE, Université Nangui Abrogoua, Abidjan, Côte d’Ivoire.

From (2,3-dihydro-1H-perimidin-2-yl)-phenyl, the substitution of OH group in ortho or para position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in para position has the lowest activity in both cases. Therefore the para position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.

Perimidine, Spectrometry, Antioxidant Activity, 2, 2-Diphenyl-1-Picrylhydrazyl Method and Ferric Reducing Antioxidant Power Method

Tiéba, T. , Baptiste, K. , Daouda, B. , Claude, K. , Guillaume, K. , Bernard, Y. and Nahossé, Z. (2021) Antioxidant Activity Evaluation in a Series of Heterocyclic Compounds Derived from 1,8-Diaminonaphthalene. Journal of Biophysical Chemistry, 12, 1-9. doi: 10.4236/jbpc.2021.121001.