Hazarders of Smoking and Helicobacter pylori Infection on Gastric Mucosa among Egyptian Patients with Dyspepsia ()
Affiliation(s)
1Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
2Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
3Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt.
ABSTRACT
Background: Smoking is hazardous to almost any organ in the body and has a harmful
effect on the gastric mucosa. Objective: The main goal of this study was
to evaluate the synergistic effect of smoking and H. pylori infection on gastric
mucosal among dyspeptic Egyptian patients. Patients and Methods: A
cross-sectional study was conducted among 240 consecutive patients with dyspepsia
who underwent upper endoscopy and histopathological examination of gastric
biopsies at Zagazig and Tanta University Hospital with H. pylori-positivity assessment
by stool antigen and rapid urease test. Results: There were 60 smoker
patients and 180 non-smoker patients. Erosive gastritis was more prevalent in
smoker patients than non-smoker patients (46.7% versus 15.6%, p = 0.00). In H. pylori-positive patients (36.7% of all patients),
smokers were more prevalent than non-smokers in the development of intestinal metaplasia (20% versus 0%, p = 0.003), erosive gastritis (80% versus 30%, p = 0.00),
glandular atrophy (20% versus 0%, p = 0.003)
and reactive gastropathy (20% versus 0%, p = 0.003). Conclusions: This study revealed that smoking may increase the prevalence of having gastric intestinal
metaplasia, erosive gastritis, glandular
atrophy and reactive gastropathy in H. pylori-positive Egyptian patients.
Share and Cite:
Salama, R. , Emara, M. and Sharawy, S. (2021) Hazarders of Smoking and
Helicobacter pylori Infection on Gastric Mucosa among Egyptian Patients with Dyspepsia.
Open Journal of Gastroenterology,
11, 1-15. doi:
10.4236/ojgas.2021.111001.