Author(s)

Louis Augustin Diaga Diouf¹, Alphonse Rodrigue Djiboune², Mamadou Soumboundou², Sidy Mouhamed Dieng³, Papa Mady Sy¹, Gora Mbaye¹, Mounibé Diarra¹

¹Pharmaceutical Physics and Biophysics Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal.
²Pharmaceutical Physics and Biophysics Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal.
³Galenic and Industrial Pharmacy Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal.

Multiple emulsions are of great therapeutic interest especially in the administration of medicines which can be inactivated by digestive enzymes; moreover the researches of formulation not being often easy, a control of the different phases physicochemical parameters would be of great interest in rapid formulations and at low cost. When formulating emulsions, the preliminary tests, also known as formulation tests, constitute a step which can be long and expensive because of the quantity of reagents that can be used. A rigorous methodology could thus be of great interest, which is at the aim of our study which consists of evaluating the physico-chemical parameters of different phases used to make thus multiple emulsions. In our study, physico-chemical parameters such as conductivity, pH, density, viscosity, and surface tension have been studied by direct measurement using equipment and also by means of suitable mounting. The results showed that the pH and the surface tension have an important role in the prediction of the stability of emulsions, these latter must be of the same order of magnitude. For all phases conductivity does not have too much interest apart from helping to determine the type of the emulsion.

Active Pharmaceutical Ingredients, Multiple Emulsions, Stability, Physico-Chemical Parameters

Diouf, L. , Djiboune, A. , Soumboundou, M. , Dieng, S. , Sy, P. , Mbaye, G. and Diarra, M. (2020) Multiple Emulsions Able to Be Used for Oral Administration of Active Pharmaceutical Ingredients: Physico-Chemical Parameters Study of Different Phases. Journal of Modern Physics, 11, 1528-1535. doi: 10.4236/jmp.2020.1110094.