Objectives: The general objective is to contribute to the promotion of the protection of professionals against STIs. Methodology: The study is quantitative of descriptive correlational type. Data were collected cross-sectionally using a questionnaire from May 01, 2019 to July 01, 2019 from sex workers living in target neighborhoods. Our study population consists of female sex workers from the above-mentioned neighborhoods, while our sample is 122 obtained on the basis of the inclusion and exclusion criteria. Results: Compared to the condom use rate: the level of use is low, because only 42.62% have already used these condoms. Regarding the links between different characteristics of sex workers and the use of female condoms: age between 20 and 29, lack of other work, income less than 50,000 FC, seniority in the work of less than 12 years, the fact of not having suffered from an STI, the fact of not having a partner with STI and the ignorance of a case of death following AIDS, are associated with low use female condoms; because their p (value) is less than 0.05. Conclusion: The cases of STIs and unwanted pregnancies in the midst of sex workers are real problems that deserve special attention, since they bear witness to the correct level of condom use. Although increasing in recent years, condom use remains low compared to estimated needs. Likewise, there is still very little applied research focused on the level of condom use among diverse populations, and more particularly among sex workers.