Pollution provoked by antibiotics and antibiotic-resistant bacteria must be placed as a worldwide health and ecological worry. Advanced oxidation processes (AOPs) are viewed as a greatly reasonable technique concerning water treatments for eliminating organic contaminants categorized as bio-recalcitrant and for the demobilization of pathogens, which are not touchable via traditional methods. This work discusses briefly the main recent facts and future trends in the field of applying AOPs in wastewater treatment. There is an urgent need for strengthening the studies on eliminating pollutants and microorganisms for wastewater reuse utilizing various AOPs. In-depth investigation about their reduction pathways employing AOPs is needed. Coupling AOPs with membrane processes should be kept in mind for better safety and pollutant removal.