Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde - Crystal Structure Theory and Applications

CSTA > Vol.8 No.4, November 2019

Crystal Structure Theory and Applications

Volume 8, Issue 4 (November 2019)

ISSN Print: 2169-2491 ISSN Online: 2169-2505

Google-based Impact Factor: 0.43 Citations

Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde ()

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DOI: 10.4236/csta.2019.84004 1,048 Downloads 3,335 Views Citations

Author(s)

Evans N. Mainsah¹, Sally-Judith E. Ntum², Mariam Asseng Conde³, George T. Chi⁴, James Raftery⁵, Peter T. Ndifon^2*

Affiliation(s)

¹Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon.
²Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
³Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon.
⁴The School of Chemistry, De Montfort University, Leicester, UK.
⁵The School of Chemistry and the School of Materials, University of Manchester, Manchester, UK.

ABSTRACT

A new hydrogen bonded Cobalt(II) Schiff base complex, N’-(pyridine-4-carboxaldehyde) isonicotinoylhydrazone Cobalt(II), has been synthesized from isoniazid and pyridine-4-carboxaldehyde and characterized by IR spectroscopy, ¹H-NMR, elemental analysis, TGA and single crystal X-ray structure determination. X-ray crystal structure analysis shows an octahedral complex with a metal centre coordinated to two ligand molecules through the pyridine nitrogen atoms and four water molecules and containing two nitrate groups as counter ions. The complex crystallizes in the monoclinic crystal system and P2(1)/n space group. The unit cell dimensions are: a = 7.2108(4) Å, b = 16.6020(9) Å, c = 13.0389(6) Å,α = 90°, β = 103.972(4)°, γ = 90°. The molecule is symmetrical about the cobalt centre as observed from the ¹H-NMR and ¹³C-NMR and confirmed by the single crystal X-ray structure of the complex. Thermogravimetric analysis shows two steps decomposition of the complex to leave a metal oxide residue. The title compound is expected to be biologically active as one of the precursors (isoniazid) is a therapeutic agent with well-established clinical applications.

KEYWORDS

Pyridine Derivatives, Cobalt(II) Complex, Isonicotinoylhydrazone, Pyridine-4-Carboxaldehyde, Schiff Base, Heterocyclic Compound, X-Ray Structure

Share and Cite:

Mainsah, E. , Ntum, S. , Conde, M. , Chi, G. , Raftery, J. and Ndifon, P. (2019) Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde. Crystal Structure Theory and Applications, 8, 45-56. doi: 10.4236/csta.2019.84004.

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