DNA-Like Duplex Structures Derived from Chemistry Based on 2’-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level ()
ABSTRACT
The new epigenetic elements 5-hydroxymethyl-dC, 5-formyl-dC, and 5-car- boxy-dC may be considered as intermediates of an
active demethylation process. A comprehensive mechanistic model is given for the C-C bond cleavage focused on the
chemistry within the DNA duplex structure. In addition we register spin-off
chemistry of this process in evaluating new duplex systems closely related to natural DNA and
RNA concerning their hydrogen-bond symmetrization. A
model is composed for a base-specific inhibition of G and C
on the DNA and RNA level. C-G combinations are of general importance in
controlling the dynamics of gene expression. In some way the suggested model
systems are related to antisense oligonucleotides (ASOs).
Share and Cite:
Buck, H. (2018) DNA-Like Duplex Structures Derived from Chemistry Based on 2’-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level.
Journal of Biophysical Chemistry,
9, 23-40. doi:
10.4236/jbpc.2018.93003.
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