The First Approved “Deuterated” Drug: A Short Review of the Concept - Pharmacology & Pharmacy

PP > Vol.9 No.10, October 2018

Pharmacology & Pharmacy

Volume 9, Issue 10 (October 2018)

ISSN Print: 2157-9423 ISSN Online: 2157-9431

Google-based Impact Factor: 0.70 Citations h5-index & Ranking

The First Approved “Deuterated” Drug: A Short Review of the Concept ()

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Download as PDF (Size: 558KB) PP. 440-446

DOI: 10.4236/pp.2018.910033 2,048 Downloads 4,334 Views Citations

Author(s)

Robert B. Raffa^1,2,3, Joseph V. Pergolizzi^1,4, Robert Taylor⁴

Affiliation(s)

¹Neumentum, Inc., Palo Alto, CA, USA.
²Colleges of Pharmacy, University of Arizona, Tucson, AZ, USA.
³Temple University School of Pharmacy, Philadelphia, PA, USA.
⁴NEMA Research, Inc., Naples, FL, USA.

ABSTRACT

The first “deuterated” drug has recently been approved by the U.S. FDA (Food & Drug Administration). A “deuterated” drug is a drug in which the hydrogen atom in one or more of the carbon-hydrogen bonds in its chemical structure is replaced by deuterium (“heavy hydrogen”, a hydrogen isotope that has a neutron, i.e., one neutron instead of the usual no neutrons). A carbon-deuterium (C-D) bond is more stable in the body than a carbon-hydrogen (C-H) bond. If the deuterium is strategically located in a drug’s chemical structure, the extra stability of the bond will be more resistant to metabolic breakdown, and the duration of drug action will be prolonged. We review the general concept of deuterated drugs, historical examples of the classes of application, and the new approval.

KEYWORDS

Deuterium, Drug Structure, Chemical Bonds, Drug Metabolism, Duration of Action

Share and Cite:

Raffa, R. , Pergolizzi, J. and Taylor, R. (2018) The First Approved “Deuterated” Drug: A Short Review of the Concept. Pharmacology & Pharmacy, 9, 440-446. doi: 10.4236/pp.2018.910033.

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