Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of Syzygium aromaticum in Albino Rats - Advances in Bioscience and Biotechnology

ABB > Vol.8 No.11, November 2017

Advances in Bioscience and Biotechnology

Volume 8, Issue 11 (November 2017)

ISSN Print: 2156-8456 ISSN Online: 2156-8502

Google-based Impact Factor: 1.18 Citations h5-index & Ranking

Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of Syzygium aromaticum in Albino Rats ()

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Download as PDF (Size: 497KB) PP. 411-420

DOI: 10.4236/abb.2017.811030 1,008 Downloads 2,386 Views Citations

Author(s)

Twadu A. Saeed¹, Osman A. Osman², Ahmed E. Amin³, Samia M. A. El Badwi^3*

Affiliation(s)

¹Ministry of Animal Resources and Fisheries, Department of Animal Quarantine, Khartoum, Sudan.
²Sudanese Standards and Metrology Organization, Khartoum, Sudan.
³Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Khartoum, Khartoum, Sudan.

ABSTRACT

The present study was undertaken to investigate the effect of the ethanolic extract of Syzygium aromaticum to albino rats. Forty eight Albino rats were employed to test the safety and the anti-inflammatory effect of the extract. Safety of the extract was examined on experimental animal’s model at three dose levels of the extract orally in daily doses for three weeks. Effects of S. aromaticum on rats revealed no significant effect on biochemical or haematological parameters. The anti-inflammatory effect of the extract was tested in four equal groups; groups 1 and 2 were treated with 250 and 500 mg/kg of the extract, respectively, group 3 was treated with indomethacine and group 4 was the untreated control. Carrageenan was used as an acute form inducer of inflammation. Indomethacine, the non-steroidal anti-inflammatory drugs (NSAIDs), was used as a reference compound. Oedema size was monitored at the 1^st, 2^nd, 4^th, 6^th and after 24 hours. The ethanolic extract of S. aromaticum showed significant (P < 0.001) decreased in the oedema size at efficacy rates of 79.41%, 82.39% and 63.92% for the dose, 500 mg/kg body weight at the 2^nd, 4^th and 6^th hour respectively higher than that produced by indomethacine.

KEYWORDS

Syzygium aromaticum, Ethanolic Extract, Safety, Anti-Inflammatory, Rats

Share and Cite:

Saeed, T. , Osman, O. , Amin, A. and Badwi, S. (2017) Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of Syzygium aromaticum in Albino Rats. Advances in Bioscience and Biotechnology, 8, 411-420. doi: 10.4236/abb.2017.811030.

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