Predictors of Negative Cone Biopsies and Its Clinical Significance ()
ABSTRACT
Objective: To determine the predictors of absence of lesion on
cone biopsy (white cone). We evaluated several factors including parity,
cytology, human papillomavirus (HPV) typing, biopsy, colposcopy, smoking habit,
use of oral contraceptive or condom, and immunosuppression as predictors for
absence of dysplasia. Methods: Of 510 patients with CIN (cervical
intraepithelial neoplasia) treated by loop electrosurgical excision (LEEP) in the Fundación Jimenez Diaz hospital between 2012 and
2016, 51 (10%) patients had a white cone and were defined as the study group.
The control group was established from two
randomly selected controls for each case (n = 102). Results: The study group had a higher
prevalence of low-grade cytology (p < 0.001), minor changes (p < 0.01), and CIN 2 (<0.001) than the control group. The study
group had a lower rate of oral contraceptive use (p = 0.005), as demonstrated by the multivariate analysis
(except for low-grade cytology). Conclusions: In conclusion, this study
indicates that the incidence of white cone in our institution is 10% of all the
cone biopsy and women with low-risk cytology, minor changes in colposcopy, CIN 2, and no use of oral contraceptive have a high
probability of having no lesions in the conization specimen.
Share and Cite:
Santana, B. and Baro, R. (2017) Predictors of Negative Cone Biopsies and Its Clinical Significance.
Open Journal of Obstetrics and Gynecology,
7, 1092-1101. doi:
10.4236/ojog.2017.711110.
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