Author(s)

Svetlana Stepanovna Moisa

Federal State-Financed Establishment of Science, State Scientific Center of Russian Federation, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.

The review contains contemporary literature data about calcitonin role in the development of insulin resistance and its potential role in the pathogenesis of carbohydrate metabolism disturbances. Analogues disturbances revealed under diabetes mellitus and under calcitonin treatment are considered. Literature data about hormone diabetogenicity are discussed. The analysis of experimental and literature data testifies that calcitonin under unfavorable conditions (age, obesity, stress) against the background of the decreasing of functional activity of insular apparatus can lead to the development of metabolic syndrome and diabetes mellitus. It is shown that calcium channel blockers inhibit calcitonin effect leads to glucose intolerance and decreases tissue insulin sensitivity. In this connection a question about direct influence on calcium mechanisms of endocrine system as possible method of drug therapy is discussed.

Calcitonin, Insulin, Insulin Resistance, Diabetogenic Effect, Risk Factor, Calcium Channel Blockers

Moisa, S. (2017) Calcitonin Participant in the Development of Insulin Resistance. Journal of Biomedical Science and Engineering, 10, 343-354. doi: 10.4236/jbise.2017.107026.