Author(s)

Julia Martin, Alberto Romero Gracia, Agustín G. Asuero

Department of Analytical Chemistry, The University of Seville, Seville, Spain.

The study of the calibration of a series of compounds of environmental concern (six perfluoroalkyl compounds (perfluorooctane sulfonic acid and five perfluoroalkyl carboxylic acids), three preservatives (methyl-, ethyl- and propylparabens) and the brominated flame retardant hexabromocyclododecane) by LC-MS/MS has been carries out, with a view to their simultaneous determination in samples of environmental interest. In some cases nonlinear calibration curves are obtained, but restricting the concentration range a linear model may be used to fit the data. Residual analysis has been performed in order to verify which models fit the data better, opting for a compromise decision given the apparent complexity of residuals plots. As Box states there are no perfect models (but models that work better than others).

Calibration, Non Linear Calibration, Residual Analysis, Liquid Chromatography-Tandem Mass Spectrometry, Emerging Pollutants

Martin, J. , Gracia, A. and Asuero, A. (2017) Fitting Nonlinear Calibration Curves: No Models Perfect. Journal of Analytical Sciences, Methods and Instrumentation, 7, 1-17. doi: 10.4236/jasmi.2017.71001.