Author(s)

Chanyi Lu^1,2, Qiqin Li^1,2,3, Yaoyao Li^1,2, Yun Wang^1,2,4, Yun-Feng Zhang^1*

¹School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
²State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health of the People’s Republic of China, Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, China.
³Lu’an People’s Hospital, Lu’an, China.
⁴Allen Institute for Brain Science, Seattle, WA, USA.

Current rodent models of the complete congenital stationary night blindness (CSNB1) were time- consuming in breeding and validation, which makes it imperative to find a more “easily handle” animal model to broaden our understanding of this disorder. In the present study, a light-deprivation (LD) mouse model was made to validate whether it was a more “suitable” animal mode for investigating the pathogenesis of the CSNB1. Compared with controls, the LD mice exhibited a remarkable reduction in the amplitude of the dark-adapted electroretinogram (ERG) b-wave, the Max-ERG b-wave and also the oscillatory potentials (Ops), indicating an abnormal activity of rod bipolar cells in the retina. However, the ERG a-wave was relatively normal in the LD mice, which was quite consistent with what was confirmed in previously reported animal models of the CSNB1 and CSNB patients. Taken together, the LD mouse model showed CSNB1-like negative ERG responses as evidenced by the abnormal b-wave. Our study will provide a potentially useful animal model to decipher the pathogenesis of the CSNB1.

Complete Congenital Stationary Night Blindness, Light-Deprivation, Electroretinogram, Oscillatory Potentials

Lu, C. , Li, Q. , Li, Y. , Wang, Y. and Zhang, Y. (2016) A Light-Deprivation Mouse Model Potentially for Studying the Complete Congenital Stationary Night Blindness. World Journal of Neuroscience, 6, 181-183. doi: 10.4236/wjns.2016.63022.