Author(s)

Vyacheslav A. Vostrikov^1,2, Boris B. Gorbunov^3*, Sergey V. Selishchev³

¹Laboratory of Clinical Pathophysiology of Critical States, Negovsky Research Institute of General Reanimatology, Moscow, Russia.
²Laboratory of Electrophysiological Methods in Cardiology, Department of Cardiology of Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia.
³Department of Biomedical Systems, National Research University of Electronic Technology, Zelenograd, Moscow, Russia.

The goal is to help create smooth energy-optimal monophasic pulse waveforms for defibrillation using the Luo-Rudy cardiomyocyte membrane computer model. The waveforms were described with the help of the piecewise linear function. Each line segment provides a transition from one present level of the transmembrane potential to the next with a minimal energy value. The duration of the last segment was defined as a minimum duration at which an action potential occurs. Monophasic waveforms of segments 3, 10 and 29 were built using different increments of the transmembrane potential. The pulse energy efficiency was evaluated according to their threshold energy ratios in mA²·ms/cm⁴. There was virtually no difference between the threshold energy ratios of the three waveforms constructed and those of the previously studied energy-optimal half- sine waveform: 241 - 242 and 243 mA²·ms/cm⁴. The pulse waveform constructed is characterized by a low rise and fall as the duration of the rise is ~1.5 times longer than that of the fall. Conclusion: Energy-optimal smooth monophasic pulse waveforms have the same threshold energy ratio as the optimal half-sine one which was studied before. The latter is equivalent to the first phase of biphasic quasisinusoidal Gurvich-Venin pulse which has been used in Russia since 1972. Thus, the use of the Luo-Rudy cardiomyocyte membrane model appears to offer no possibilities for a substantial increase in the energy efficiency (threshold energy ratio reduction) of the classical monophasic defibrillation pulse waveforms.

Energy-Optimal Defibrillation Pulse Waveform, Monophasic Defibrillation Pulse Waveforms, Modeling, Energy Ratio, Cardiomyocyte, Transmembrane Potential, Action Potential

Vostrikov, V. , Gorbunov, B. and Selishchev, S. (2015) Construction of Energy-Optimal Smooth Monophasic Defibrillation Pulse Waveforms Using Cardiomyocyte Membrane Model. Journal of Biomedical Science and Engineering, 8, 625-631. doi: 10.4236/jbise.2015.89058.