Pituitary Function in the Acute Phase of Traumatic Brain Injury and Subarachnoid Hemorrhage - International Journal of Clinical Medicine

IJCM > Vol.6 No.6, June 2015

International Journal of Clinical Medicine

Volume 6, Issue 6 (June 2015)

ISSN Print: 2158-284X ISSN Online: 2158-2882

Google-based Impact Factor: 0.52 Citations h5-index & Ranking

Pituitary Function in the Acute Phase of Traumatic Brain Injury and Subarachnoid Hemorrhage ()

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Download as PDF (Size: 561KB) PP. 411-422

DOI: 10.4236/ijcm.2015.66054 3,183 Downloads 4,002 Views Citations

Author(s)

Anna Tölli^1*, Jörgen Borg¹, Bo-Michael Bellander², Charlotte Höybye³

Affiliation(s)

¹Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
²Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Stockholm, Sweden.
³Department of Molecular Medicine and Surgery, Karolinska Institutet and Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden.

ABSTRACT

Background: Pituitary insufficiencies after traumatic brain injury (TBI) and subarachnoid haem-orrhage (SAH) have been reported with very varying frequencies. The aim of this study was to describe the pituitary function in the acute phase after TBI and SAH in a cohort of adults and relate the results to injury variables. Methods: Adults admitted to the neurointensive care unit in our hospital after moderate and severe TBI or SAH were included prospectively. Demographic, clinical, laboratory, including ACTH stimulation test, and radiological data were collected. Results: A total of 130 adults, 84 (19 women/65 men) with TBI and 46 (38 women/8 men) with SAH were included. Nine patients with TBI and six patients with SAH responded insufficiently to ACTH stimulation; 14 patients with TBI and 9 patients with SAH had low fT4 and low-normal TSH levels. No relations were seen between hormonal levels and injury variables. Conclusions: Pituitary deficiencies occur after TBI and SAH, and a continuous endocrine evaluation of these patients is important. Our study could not define a marker for increased risk for pituitary deficiency. The long-term clinical outcome of the pathological hormone levels in the early phase after TBI and SAH is not known in detail and further studies to elucidate this are needed.

KEYWORDS

Hormone Disturbance, Pituitary, Traumatic Brain Injury, Subarachnoidal Haemorrhage

Share and Cite:

Tölli, A. , Borg, J. , Bellander, B. and Höybye, C. (2015) Pituitary Function in the Acute Phase of Traumatic Brain Injury and Subarachnoid Hemorrhage. International Journal of Clinical Medicine, 6, 411-422. doi: 10.4236/ijcm.2015.66054.

Cited by

[1]	Prevalence of Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis
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[2]	Impact of pituitary dysfunction on cognitive and global outcome after traumatic brain injury and aneurysmal subarachnoid haemorrhage
	2019

[3]	Impact of pituitary dysfunction on cognitive and global outcome after traumatic brain injury and aneurysmal subarachnoid haemorrhage.
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[4]	The effect of time on cognitive impairments after non-traumatic subarachnoid haemorrhage and after traumatic brain injury
	Brain Injury, 2018

[5]	Clinical prevalence and outcome impact of pituitary dysfunction after aneurysmal subarachnoid hemorrhage: a systematic review with meta-analysis
	Pituitary, 2016

[6]	Chiara Robba, Susanna Bacigaluppi, Nicola Bragazzi, Andrea Lavinio, Mark Gurnell, Federico Bilotta & David
	2016

[7]	Pituitary function within the first year after traumatic brain injury or subarachnoid haemorrhage
	Journal of Endocrinological Investigation, 2016

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