Author(s)

Natalya Arkhipova, Elena Popova, Lena Grigorieva

Yakutsk Science Centre of Complex Medical Problems, Siberian Branch of the Russian Academy of Medical Science, Yakutsk, Russia.
Мedical Institute, North-Eastern Federal University Named after M. K. Ammosov, Yakutsk, Russia.

The study of ACE gene I/D polymorphism has been carried out in elderly, senile and long-liver patients with coronary heart disease (CHD) taking into account their nationality, age and sex. It has been recorded that with the increase of age there is a decrease in the frequency of the genotype ACE*I/*I and a tendency of increase in the frequency of the genotype ACE*D/*D. A comparative analysis of genotypes АСЕ*D/*D and АСЕ*D/*I has showed sex differences in the frequency of homozygous genotype detection. Left ventricular hypertrophy can be observed significantly more often among carriers of genotype ACE*I/*I established by Sokolow-Lyon ECG signs. Association analysis of ACE gene I/D polymorphism has registered significant differences in BMI and blood lipid parameters.

CHD; Geriatric Age; Risk Factors; ACE Gene; Non-Indigenous and Yakut Patients

Arkhipova, N. , Popova, E. and Grigorieva, L. (2014) The angiotension converting enzyme (ACE) gene I/D polymorphism in different ethnic groups of geriatric age living in the Far North. Health, 6, 426-431. doi: 10.4236/health.2014.65060.