Run-off-road crashes in the United States have become a major cause of serious injuries and fatalities. A significant portion of run-off-road crashes are single vehicle crashes that occur due to collisions with fixed objects and overturning. These crashes typically tend to be more severe than other types of crashes. Single vehicle run-off-road crashes that occurred between 2004 and 2008 were extracted from Kansas Accident Reporting System (KARS) database to identify the important factors that affected their severity. Different driver, vehicle, road, crash, and environment related factors that influence crash severity are identified by using binary logit models. Three models were developed to take different levels of crash severity as the response variables. The first model taking fatal or incapacitating crashes as the response variable seems to better fit the data than the other two developed models. The variables that were found to increase the probability of run-off-road crash severity are driver related factors such as driver ejection, being an older driver, alcohol involvement, license state, driver being at fault, medical condition of the driver; road related factors such as speed, asphalt road surface, dry road condition; time related factors such as crashes occurring between 6 pm and midnight; environment related factors such as daylight; vehicle related factors such as being an SUV, motorcycles, vehicle getting destroyed or disabled, vehicle maneuver being straight or passing; and fixed object types such as trees and ditches.