The prolactin-inducible-protein (PIP): A regulatory molecule in adaptive and innate immunity - Open Journal of Immunology

OJI > Vol.3 No.4, December 2013

Open Journal of Immunology

Volume 3, Issue 4 (December 2013)

ISSN Print: 2162-450X ISSN Online: 2162-4526

Google-based Impact Factor: 0.91 Citations

The prolactin-inducible-protein (PIP): A regulatory molecule in adaptive and innate immunity ()

HTML XML

Download as PDF (Size: 180KB) PP. 210-217

DOI: 10.4236/oji.2013.34026 4,847 Downloads 8,426 Views Citations

Author(s)

Vivake Umadat, Olivia Ihedioha, Robert Shiu, Jude Uzonna, Yvonne Myal

Affiliation(s)

Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Department of Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada;.

ABSTRACT

The Prolactin-inducible-protein (PIP)/Gross Cystic Disease Fluid Protein-15 (GCDFP-15) gene is highly expressed in salivary, lacrimal and sweat glands and the protein abundantly found in the secretions that originate from these glands; saliva, tears and sweat. PIP is thus considered to be strategically located at sites viewed as the first port of entry for invading organisms. PIP is also found over-expressed under abnormal and pathological conditions of the breast and prostate. The function of PIP has yet to be defined but it has been implicated to play a role in immunity, with respect to bacterial and viral infection, cancer and fertility. Despite such predictive functions, there is still no clear demonstration of an immunoregulatory role for PIP. In this review we will focus on accumulating evidence that suggests a role for PIP in both innate and adaptive immunity. Moreover, we will discuss recent evidence that defines a modulatory role for PIP with regards to a CD4⁺ T cell immune response, identifying for the first time, a critical role for PIP in effective cell-mediated immunity against an intracellular pathogen.

KEYWORDS

Prolactin-Inducible-Protein (PIP); Immunoregulation; Innate Immunity; Adaptive Immunity

Share and Cite:

Umadat, V. , Ihedioha, O. , Shiu, R. , Uzonna, J. and Myal, Y. (2013) The prolactin-inducible-protein (PIP): A regulatory molecule in adaptive and innate immunity. Open Journal of Immunology, 3, 210-217. doi: 10.4236/oji.2013.34026.

Cited by

[1]	Tear proteomics analysis of patient suffered from delayed mustard gas keratopathy
	Proteome …, 2022

[2]	Proteomic profile of vitreous in patients with tubercular uveitis
	2021

[3]	Glycoproteins Presenting Galactose and N-Acetylgalactosamine in Human Seminal Plasma as Potential Players Involved in Immune Modulation in the Fertilization …
	2021

[4]	Proteome of cat semen obtained after urethral catheterization
	2020

[5]	Untersuchung und Validierung der humanen Proteinglycosylierung hinsichtlich der Eignung als Biomarker anhand der Proteine β2-Glycoprotein I und Prolactin …
	2020

[6]	Development of transplantable mouse models to assess the role of prolactin inducible protein in breast tumorigenesis
	2019

[7]	The prolactin inducible protein/gross cystic disease fluid protein-15 deficient mice develop anomalies in lymphoid organs
	2019

[8]	Antibody against synthetic peptide of prolactin-inducible protein homologue precursor (PIP-HP) of Bali Cattle (Bos javanicus) saliva as a potential biomarker for …
	2018

[9]	Is infection the possible initiator of disc disease? An insight from proteomic analysis
	European Spine Journal, 2017

[10]	iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis
	Archives of Dermatological Research, 2016

[11]	Effet du liquide séminal sur l'infection par le VIH-1 dans des modèles cellulaires et tissulaires et recherche des facteurs modulateurs
	Thesis, 2014

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies