This paper presents the significance analysis of a new type of hybrid composite sandwich wall panel which can be manufactured as modular panelised system. Two different types of natural fibers reinforced plastics (NFRP) laminate were incorporated into the new sandwich panel as an intermediate layer. The significance analysis in this research has been carried out using analysis of variance (ANOVA). As the aim of the analysis is to select the most appropriate natural fiber composites for the intermediate layer, the experiments were arranged as a single factor experiment in which 3 levels of a factor have been examined. The factor refers to the type of intermediate layer used in the sandwich panel. The result of this study shows that the incorporation of intermediate layer has significantly enhanced the load carrying capacity of the sandwich panels.