Redox Factor-1 Mediates Inflammatory Response during Tumor Promotion in Skin Epidermal JB6 Cells - Open Journal of Apoptosis

OJApo > Vol.1 No.3, October 2012

Open Journal of Apoptosis

Volume 1, Issue 3 (October 2012)

ISSN Print: 2168-3832 ISSN Online: 2168-3840

Google-based Impact Factor: 1.5 Citations

Redox Factor-1 Mediates Inflammatory Response during Tumor Promotion in Skin Epidermal JB6 Cells ()

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DOI: 10.4236/ojapo.2012.13003 3,306 Downloads 10,897 Views Citations

Author(s)

Delira Robbins, Wenjuan Li, Katie Humphrey, Yunfeng Zhao

Affiliation(s)

Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, USA.
Southwood High School, Shreveport, USA.

ABSTRACT

Recently, redox factor-1 (Ref-1) has received considerable attention as an enzyme for stimulating tumor cell growth. We hypothesized that Ref-1 is upregulated during the early stage of tumorigenesis. Utilizing both tumor promotion sensitive P+ and promotion resistant P? mouse skin epidermal JB6 cells, we found that Ref-1 expression was only induced in tumor promotion sensitive P+ cells following TPA treatment. Consistent with that, Ref-1 knockdown suppressed skin cell transformation. Interestingly, Ref-1 knockdown suppressed nuclear translocation of NF-kappaB subunit p65, and inhibited production of proinflammatory cytokines. These results suggest Ref-1 may promote early tumorigenesis and serve as a target for chemoprevention.

KEYWORDS

Ref-1; Tumorigenesis; JB6 Cells; Tumor Promotion; Chemoprevention

Share and Cite:

Robbins, D. , Li, W. , Humphrey, K. and Zhao, Y. (2012) Redox Factor-1 Mediates Inflammatory Response during Tumor Promotion in Skin Epidermal JB6 Cells. Open Journal of Apoptosis, 1, 19-24. doi: 10.4236/ojapo.2012.13003.

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