Author(s)

Gisele Mara Silva Gonçalves, Andre Bernardo de Camargo Eisingher

Postgraduate Program in Health Sciences, Pontifical Catholic University of Campinas (PUC-Campinas), Campinas, Brazil.

Silymarin, from the fruit of Silybum marianum, is known for its hepatoprotective action. The aim of this study was to review the mechanisms of action of the silymarin phytocomplex to expand the possibilities for its application in human health. The search for published articles was carried out on the CAPES Journals Portal platform, which covers worldwide scientific databases. Publications from 2010 to 2022 were included. Of the 311 articles retrieved, 21 were included. The articles discuss the diversity of silymarin’s applications and the possibility of optimizing its bioavailability using drug delivery systems. Silymarin shows promise in numerous diseases, such as liver, kidney, cardiovascular, respiratory and others. Its antiviral action has been demonstrated in studies and silymarin has the potential to be used as a complementary therapy in the treatment of many diseases, with the expectation that, in the future, it will be used in therapeutic protocols for exclusive use.

Silymarin, Flavonoids, Phytotherapeutic Drugs

Gonçalves, G. and de Camargo Eisingher, A. (2024) Possible Uses for Silymarin in Human Health: Systematic Review. American Journal of Plant Sciences, 15, 95-109. doi: 10.4236/ajps.2024.152007.