Author(s)

Mei Li¹, Dalin Song², Zhu Meng², Junquan Zhao^2*

¹Department of Clinical Laboratory, University of Health and Rehabilitation Sciences Qingdao Hospital & Qingdao Municipal Hospital, Qingdao, China.
²Department of Cadre Health Care, University of Health and Rehabilitation Sciences Qingdao Hospital & Qingdao Municipal Hospital, Qingdao, China.

Objective: To investigate the protective effect of nitrates postconditioning on myocardial ischemia-reperfusion injury and whether it plays a regulatory role in TNF-α in patients with STEMI during PCI. Methods: Patients with STEMI who underwent PCI were selected, except for obvious anemia, head trauma, cerebral hemorrhage, hypotension (systolic blood pressure less than 90 mmHg), and patients with autoimmune diseases, all kinds of acute and chronic infections and malignant tumors. They were randomly divided into PCI standardized treatment group and isosorbide dinitrate postconditioning during PCI group. The concentrations of cTnI and TNF-α in serum were detected by ELISA method in each group before PCI and after 2 hours, 1 day, 4 days and 7 days of PCI. Results: 1) There were no statistically significant differences in sex, age, smoking history, diabetes, hypertension and blood lipid abnormality in two groups. 2) Before operation, the concentration of cTnI in two groups was not statistically significant. The concentration of cTnI in the experimental group was lower than that of the control group after 4 days and 7 days of PCI, and P < 0.05, the difference was statistically significant. The concentration of cTnI reached the peak in 1 day after operation in the control group, while the experimental group was in 2 hours after operation, and the cTnI concentration in the experimental group at each time point was lower than that of the control group. 3) There was no statistical difference in the concentration of TNF-α in two groups before operation. The concentration of TNF-α in the experimental group was lower than that in the control group after 1 day, 4 days and 7 days of PCI, and P < 0.05, the difference was statistically significant. The peak value of TNF-α in two groups was both in 1 day after operation, and the peak level of the experimental group and the level of each time after the operation were lower than that of the control group. Conclusion: Nitrates postconditioning during PCI in patients with STEMI has a protective effect on myocardial ischemia-reperfusion injury. Nitrates postconditioning has an effect to reduce the level of TNF-α of patients with STEMI after PCI treatment, and may have the mechanism of alleviating the inflammatory response after myocardial ischemia and reperfusion.

Ischemia-Reperfusion Injury (IRI), Pharmacological Postconditioning, Nitrates, TNF-α

Li, M. , Song, D. , Meng, Z. and Zhao, J. (2023) Continuous Monitoring of Serum Tumor Necrosis Factor-α for Patients with TEMIS Treated by Nitrates Postconditioning during PCI. Journal of Biosciences and Medicines, 11, 200-208. doi: 10.4236/jbm.2023.1110019.