Author(s)

Yu Feng, Min Guo^*

Department of Gastroenterology, The Fourth People’s Hospital of Haikou, Haikou, China.

Objective: The aim is to observe the protective effect of baicalin on trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis in mice and explore its mechanism. Methods: The mice were divided into 4 groups: ethanol control group, TNBS model group, baicalin low-dose group and baicalin high-dose group. The model of experimental colitis in mice was induced by TNBS enema. After 2 hours of TNBS enema, baicalin was given by gavage, QD × 7D. The animals were sacrificed on the 8th day to observe the extent of colonic mucosal damage, and the Peroxidase activity, Malondialdehyde (MDA) and glutathione (GSH) contents were measured. Results: Compared with the TNBS model group, the body weight, gross injury score and histological changes were significantly improved; MPO enzyme activity and MDA content were significantly decreased in the low and high-dose baicalin groups; and the content of glutathione increased. Conclusion: Baicalin can alleviate TNBS-induced colitis in mice, and the mechanism is related to the antioxidation of baicalin.

Baicalin, Trinitrobenzene Sulfonic Acid, Experimental Colitis, Mouse

Feng, Y. and Guo, M. (2023) Effect of Baicalin on TNBS-Induced Colonic Inflammatory Injury in Rats. Health, 15, 938-943. doi: 10.4236/health.2023.159062.